International Journal for Research in Applied Science & Engineering Technology (IJRASET) ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538 Volume 11 Issue IV Apr 2023- Available at www.ijraset.com III. RESULT AND DISCUSSION A. QRA Sheet Performed Area Quantity Inherent Unit Duration of per Physical Hazard Inherent Value Value Value Value Value Risk Operation Exposure Batch/Acti Form Classification Risk Calculation vity API PART-A Closed System transfers 3 <30 minutes 1 >50 kg or >50 liters 5 Low VP Solvents API PART-A Sampling 1 <30 minutes 1 <100 grams or < 100 ml 1 Low VP Solvents API PART-A API PART-A API PART-A Dischargin g Charging Charging API PART-A Charging API PART-A Liquid Drum Charging 4 <30 minutes 4 <30 minutes 4 <30 minutes 4 <30 minutes 2 <30 minutes 1 1-50 kg or 150 liters 1 1-50 kg or 150 liters 1 1-50 kg or 150 liters 1 1-50 kg or 150 liters 1 1-50 kg or 150 liters 4 Low VP Solvents 4 API/ interme diate/ RSM 4 API/ interme diate/ RSM 4 Low VP Solvents 4 High VP Solvent 4 OEB 4 ( >1<10ug/m3); TLV 6-20 ppm 4 240 4 OEB 4 ( >1<10ug/m3); TLV 6-20 ppm 4 16 4 OEB 4 ( >1<10ug/m3); TLV 6-20 ppm 5 OEB 1 ( >1000 ug/m3); TLV >501 ppm 5 OEB 1 ( >1000 ug/m3); TLV >501 ppm 1 1-50 kg or 150 liters 4 Low VP Solvents 4 API PART-A Sampling 1 <30 minutes 1 <100 grams or < 100 ml 1 Low VP Solvents 4 OEB 4 ( >1<10ug/m3); TLV 6-20 ppm 4 <30 minutes 1 1-50 kg or 150 liters 4 Granulat e Material 3 OEB 1 ( >1000 ug/m3); TLV >501 ppm 1 64 256 4 1024 80 Open handling Lowwith local Medium exhaust ventilation 4 320 Open handling Mediumwith local High exhaust ventilation 4 1024 Low Open handling with local exhaust ventilation 4 64 Low Open handling with local exhaust ventilation 16 1 4 Open handling Mediumwith local High exhaust ventilation 4 <30 minutes Open handling with local exhaust ventilation Low 80 256 4 240 Open handling Lowwith local Medium exhaust ventilation 4 Charging 1 80 5 2 Closed MediumSystem High Transfers Open handling Lowwith local Medium exhaust ventilation OEB 2 ( >100<1000 ug/m3); TLV 101-500 ppm 4 Residual Residual Risk Risk Calculation 256 OEB 4 ( >1<10ug/m3); TLV 6-20 ppm API PART-A Charging 1 Value Open handling Mediumwith local High exhaust ventilation 4 OEB 4 ( >1<10ug/m3); TLV 6-20 ppm API PART-A 4 Controls 48 4 1024 Actions Perform air monitoring; Ensure Medium effectiveness of current controls, including respiratory protection Low Periodically reevaluate; Review RA when changes or new information becomes available Perform air monitoring; Medium- Ensure High effectiveness of current controls, including respiratory protection Periodically re- 4 320 Low- evaluate; Medium Review RA when changes or new information becomes available Periodically re- 4 320 Low- evaluate; Medium Review RA when changes or new information becomes available Perform air monitoring; Medium- Ensure High effectiveness of current controls, including respiratory protection Periodically re- 4 192 ©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | Low- evaluate; Medium Review RA when changes or new information becomes available Perform air monitoring; Medium- Ensure High effectiveness of current controls, including respiratory protection Low Low Periodically reevaluate; Review RA when changes or new information becomes available Periodically reevaluate; Review RA when changes or new information becomes available 1691

Integrated Approach on Industrial Hygiene Program for Pharmaceutical Industry