Ketoconazole is a broad spectrum imidazole antifungal agent marketed as creams and tablets. It interacts with 14- demethylase, a cytochrome P-450 enzyme and inhibits ergo sterol synthesis and increased fungal cellular permeability and is used against a wide variety of fungi and yeast .Nano technology scales up to one billionth of a meter Generally, they are considered to be in range of 100nm to 1000nm.