Drugs with low aqueous solubility show limited oral bioavaibility and dissolution enhancement is a promising strategy for improving drug bioavailability. Co-crystallization is a promising technique used to improve the oral solubility and dissolution rate of the drugs and hence their oral bioavailability. In general pharmaceutical co-crystals improve the physical properties such as crystallinity, solubility, wettability and dissolution behaviors of the drug without altering its pharmacological activity. The aim of this study was to enhance the solubility, dissolution rate and limited oral bioavailability of glimepiride (GLM) by cocrystallization with different carboxylic acid co-formers. Different co-crystal formulations were successfully prepared by ultrasound assisted suspension co-crystallization technique and then suspected to solubility study to choose the best formula to complete the study.
