Coronavirus Disease-2019, known as COVID-19, has been declared a public health emergency of worldwide concern [1-4]. This paper reports a new design of Surface Enhance Raman Spectroscopy (SERS) substrate that can deliver higher sensitivity and the closest interaction to the target structure of the hot spots for the immunomagnetic capturing based concentration method. This substrate contains Polydimethylsiloxane(PDMS) inverted nanocavity arrays, which can funnel the light to the top where plasmonic gold nanorods occur. A high reflective and low loss layer is deposited at the outer surface,which reflects the photons multiple times and hence the number of photons is increased. After monitoring the consistent pattern and geometric shape of inverted cavities, the hot spots of the suggested Surface Enhance Raman Spectroscopy (SERS) substrate might have improved influence of 1010or even higher, which could be sufficient to discover .
