Background: Tuberculosis (TB) is one of the most infectious diseases in the present scenario that is caused when
Mycobacterium tuberculosis is found in the body. As tuberculosis is a communicable disease or transferrable disease, it is easily
transmitted to another person who remains in contact with the infected person through the inhalation process of air droplets
carrying that particular bacteria. The in silico study was carried out to inhibit the activity of INHA by drug molecule with the
help of molecular docking to treat tuberculosis.
Methods: All studies were based on molecular docking. Docking was carried out between all the ligands and target protein
INHA (PDB ID: 5VRL) with the help of docking software. We selected some natural compounds as ligand like Thiophenes,
Sulfonamides, Chalcone, Nitroimidazole, Benzimidazole, Lidamycin and Quinolone and INHA (PDB ID: 5VRL) as a target
protein. After the protein preparation by Biovia Discovery Studio Visualizer we imported all the ligand in PyRx software for