Dental caries is one of the most established and worldwide disease of prehistoric and current times. Sugars and their
substitutes play an important role in the prevention of dental caries, oral health preventive programmes have to go beyond
focusing solely on relation between sugar intake and dental caries. In this study there is an attempt was made to compare various
sugar substitutes and their antimicrobial properties. There was no report on the comparative analysis of various sugar
substitutes and their antimicrobial properties. The present study is carried out by analysing the phytochemicals present in
various sugar substitutes and also their antimicrobial activities by using E. coli, Staphylococcus aureus, Vibrio cholerae,
Klebsiella pneumonia, Pseudomonas aeruginosa. In this study, palm sugar shows the better activity against oral bacteria than
other sugar substitutes.