Change point analysis is a technique for detecting change in trend over time. Seg- mented regression
analysis and joinpoint analysis are used to try to determine the most important interventions which impact rates of healthcare
associated infections (HAIs). AiMs: Use change point analysis to determine which interventions reduce rates of HAIs. Data and
Methods: The data on HAIs was monitored by Health Protection Scotland (HPS) and includes staphylococcus aureus
bacteraemia (SAB) and clostridium difficile infection (CDI). Since 2004, several interventions were implemented by NHS to
reduce the rates and these were reported by Health Protection Scotland (HPS). Segmented regression and joinpoint models are
investigated and developed to detect times when the indection rates changed significantly. Profile likelihood and bootstrapping
are used to construct confidence intervals for the joinpoints.