The coronavirus outbreak in recent times has created a terrific pandemic situation in the universe. We aim to identify
the specific domain in the viral particle responsible for binding into the host cell and for finding any anti-viral drug that could
inhibit the binding interaction. Using pharmacophore-based drug modelling for drug molecule that can inhibit the spike protein
interaction is targeted. Spike protein of a viral body (SARS-CoV-2) represents a structure that acts as the ligand that binds with
the host, made up of several repeats of Beta sheets acts as the substrate-binding domain part. The anti-viral drug or the antibody
inhibit the interaction between the spike and the receptor, are predicted via receptor-ligand interaction of the desired or
predictable drug molecule.