Organo-fluorine derivatives have occupied centre-stage of studies by chemists and pharmacologists for the
pharmacological properties of various members of the group. Further to the discovery and widespread use of fluoroquinolones
and their efficacy as antibacterial agents against numerous strains of resistant bacteria, these have been extensively synthesized
and investigated for their antimicrobial properties. The widespread use of organo- fluorine derivatives has increased the
demand for the development of practical and simple reagents and experimental strategies for the incorporation of fluorine into
all types of molecular structures and this was the reasoning behind this study. The work embodied here represents the study of
reaction of 2- fluoro and 4- fluoro aniline with diethyl malonate.
