While the implementation of a SARS CoV2 vaccine is slow in coming. Several countries around the world are in the
midst of a second wave of the COVID-19 pandemic. Current data shows considerable progress but also very questionable and
sometimes contradictory results. Studies in silico optimize the time and cost of research. This exhaustive review on Pubmed,
attempts to examine all the approaches in silico addressed since the start of fight against COVID 19, which have involved
hydroxychloroquine and or chloroquine alone, combined or compared to other therapeutic agents such as antivirals. ,
phytochemicals and many more. Were used as targets, proteins involved in the pathways by which this virus enters host cell:
Main protease COVID-19, receptor binding domain of SRAS-CoV-2 Spike protein, peak protein of SRAS -CoV-2 and envelope
protein necessary in maturation processes of virus. .
