Current therapeutic limitations of bone graft substitutes drive the development of multifunctional grafts where the
bioactive flavonoids with osteogenic potential can be incorporated into three-dimensional porous bone regeneration scaffolds.
The aim of this review is to explore the possibility of fabricating nanocomposite scaffolds incorporated with widely available and
non-toxic flavonoid formulation for repair and regeneration of bone tissue. This review summarizes different bone regeneration
strategies based on porous scaffolds and provides an overview of the most widely preferred methods for obtaining porous
polycaprolactone scaffolds. Further, we intend to outline flavonoids and their classification, and have listed a few of them used
for in vitro bone tissue engineering applications. Finally, we aim to show the prospects of flavonoids to be incorporated into
nanocomposite porous scaffolds based on polycaprolactone for sustained release of flavonoids to enhance bone regeneration
