Streptozotocin (STZ) is a broad-spectrum antibiotic, belonging to nitroso group, used mostly for induction of diabetes
in laboratory animals. Induction of diabetes is mediated through glucose transporter (GLUT2) which helps entry of STZ in β
cells of islets of Langerhans of pancreas, leading to cell death by ATP depletion and oxidative stress. Additional possible factors
involving in cell death and apoptosis include alteration in cellular metabolism and impaired function of mitochondria. One of
the limitations in use of STZ is genotoxicity along with other side effects. More frequent reports of Multi-Drug resistance (MDR)
of microbes, have been available recently which have increased pressure on pharmaceutic industry to explore possibility of use
of previously known agents with antibacterial properties. STZ is a potential candidate that needs further detailed research for its
use as an antibiotic, along with use in treatment of pancreatic tumors. The present review has made an effort to know the
properties of
