Cellular Nutrition and Its Influence on Age-Associated Cellular Decline

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Cellular Nutrition and Its Influence on Age-Associated Cellular Decline (AACD)

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Researchers have identified several molecular pathways and cellular processes that appear to underlie both aging and age-related chronic disease.

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Cellular changes associated with aging are cumulatively referred to as age-associated cellular decline (AACD) and include defects in mitochondrial function.

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Identifying AACD risk factors and intervening with dietary modifications earlier in the aging process, before major mobility disabilities and disease-driven limitations emerge, could help improve overall healthy aging.

Many risk factors are associated with AACD.

Risk Factors Associated With A ACD Clinical Risk Factors

linical conditions • C(e.g., cancer, cardiovascular, renal, or metabolic disease)

• Obesity • Unfavorable genetic background • Insulin resistance • Low physical capacity (e.g., slow gait speed,

muscle weakness)

Source: Reference 1.

Behavioral/Environmental Risk Factors

• Smoking • Sedentary lifestyle • Low physical activity • Persistent physical or psychological stress • Low socioeconomic status • Alcohol abuse • Inadequate nutrition • Air pollution


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