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Robust Analytics and Reporting

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▪ Connect automatically grades assignments and quizzes, providing easy-to-read reports on individual and class performance.

More students earn As and Bs when they use Connect.

Trusted Service and Support

▪ Connect integrates with your LMS to provide single sign-on and automatic syncing of grades. Integration with Blackboard®, D2L®, and Canvas also provides automatic syncing of the course calendar and assignment-level linking.

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Connecting Instructors and Students to Additional Digital Resources

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McGraw-Hill Campus integrates all of your digital products from McGraw-Hill Education with your school’s Learning Management System for quick and easy access to best-in-class content and learning tools.

Dietary Analysis Tool

NutritionCalc Plus is a powerful dietary analysis tool featuring more than 30,000 foods from the ESHA Research nutrient database, which is comprised of data from the latest USDA Standard Reference database, manufacturer’s data, restaurant data, and data from literature sources. NutritionCalc Plus allows users to track food and activities, and then analyze their choices with a robust selection of intuitive reports. The interface was updated to accommodate ADA requirements and modern mobile experience native to today’s students. This tool is provided complimentary in Connect with Perspectives in Nutrition.

Presentation Tools allow you to customize your lectures

Enhanced Lecture Presentations Contain lecture outlines, art, photos, and tables. Fully customizable, adapted for ADA compliance, complete, and ready to use—these presentations will streamline your work and let you spend less time preparing for lecture!

Editable Art Fully editable (labels and leaders) line art from the text

Animations Over 50 animations bring key concepts to life, available for instructors and students.

Digital Lecture Capture

Tegrity® is a fully automated lecture capture solution used in traditional, hybrid, “flipped classes” and online courses to record lessons, lectures, and skills.

Connecting Students to Today’s Nutrition

Our Intended Audience

This textbook was developed for students pursuing nutrition and health science careers as well as those wanting a better understanding of how nutrition affects their lives. Because this course often attracts students from a broad range of majors, we have been careful to include examples and explanations that are relevant to them and to include sufficient scientific background to make the science accessible to them. The appendices help students who wish to learn more or need assistance with the science involved in human physiology, chemistry, and metabolism.

To better bridge the span of differing science backgrounds and to enhance student interest and achievement of course objectives, we organized the presentation of the material within chapters to flow seamlessly from concrete to abstract learning. In chapters focusing on nutrients, for example, concrete concepts, such as food sources of the nutrients and recommended intakes, are introduced early in the chapter to create a framework for more abstract concepts, such as functions, digestion, and absorption.

Accurate, Current Science That Engages Students

The eleventh edition continues the tradition of presenting scientific content that is reliable, accurate, and up-to-date. This edition incorporates coverage of recent nutrition research, as well as the recent updates to consumer guidelines and tools—Dietary Guidelines for Americans, MyPlate, Healthy People 2020, and the new Nutrition Facts panel. It also retains the in-depth coverage students need to fully understand and appreciate the role of nutrition in overall health and to build the scientific knowledge base needed to pursue health-related careers or simply live healthier lives. To enhance these strengths and promote greater comprehension, new research findings and peer-reviewed references are incorporated and artwork is enhanced to further complement the discussions. The presentation of complex concepts was scrutinized to increase clarity through the use of clear, streamlined, precise, and student-friendly language. Timely and intriguing examples, illustrative analogies, clinical insights, culinary perspectives, historical notes, future perspectives, and thoughtprovoking photos make the text enjoyable and interesting to students and instructors alike.

Allergies, including food allergies, involve responses of the immune system designed to eliminate foreign proteins (antigens). Food allergy responses occur when the body mistakenly reacts to a food as though it were a harmful invader. In some people, certain food components, typically proteins (called allergens), cause hypersensitivity reactions and trigger this response. These allergens stimulate white blood cells to produce antibodies (mostly, the immunoglobulin IgE) that bind to antigens and cause the symptoms associated with an allergic reaction.15

Fortunately, most allergic reactions are mild, such as a runny nose, sneezing, itching skin, hives, or digestive upset (indigestion, nausea, vomiting, diarrhea). For those who are severely allergic, exposure to the allergenic food may cause a generalized, life-threatening reaction involving all body systems (known as anaphylaxis or anaphylactic shock).

Anaphylaxis causes decreased blood pressure and respiratory distress so severe that the person cannot breathe—death will occur

without immediate medical help. In the U.S., allergic reactions result in 200,000 emergency room visits and 150 to 200 deaths per year.

The protein in any food can trigger an allergic reaction. However, 8 foods account for 90% of all food allergies: peanuts, tree nuts (e.g., walnuts and cashews), milk, eggs, fish, shellfish, soy, and wheat (Fig. 7-16). Other foods frequently identified as causing allergic reactions are meat and meat products, fruits, and cheese.

The only way to prevent allergic reactions is to avoid foods known to trigger reactions. Carefully reading food labels and asking questions when eating out are essential, perhaps life-saving, steps for those with food allergies.15 In addition, individuals preparing foods at home or in restaurants need to know their menu ingredients and take steps to ensure that foods that cause an allergic reaction in a person do not come in contact with the food to be served to that individual. Even trace amounts of an allergen can cause a reaction.

To prevent cross-contact, anything that will be used to prepare an allergen-free meal (e.g.,

Food Protein Allergies

Connecting with a Personal Focus

Applying Nutrition on a Personal Level

A key objective in nearly all introductory courses is for students to apply their new knowledge of nutrition to their own lives. Practical applications clearly linked to nutritional science concepts are woven throughout each chapter to help students apply their knowledge to improving and maintaining their own health and that of others for whom they are responsible, such as future patients or offspring.

• Take Action features in each chapter allow students to examine their own diets and health issues.

• Updated case studies showcase realistic scenarios and thoughtprovoking questions.

• New discussion of the Nutrition Facts panel outlines the innovative changes to this important consumer tool.

Applying Nutrition to Career and More

5.4 Functions of Carbohydrates in the Body

The EPA requires that the public be notified if water contamination is a danger to public health. For instance, nitrate con tamination from fertilizer runoff is particularly dangerous to infants because it prevents oxy gen from circulating in the body. As related earlier, Cryptosporidium can contaminate water supplies (it is not affected by nor mal chlorination procedures). Boiling tap water for a minimum of 1 minute is the best way to kill Cryptosporidium Alternatively, individuals can purchase a water filter that screens out this parasite. Even though the U.S. has one of the cleanest water supplies in the world, illnesses from contaminated drinking water do occur. The CDC monitors water-related outbreaks, which average about 30 per year.63 Water safety experts note that these data likely underestimate the true number of illnesses caused by contaminated water.

Digestible Carbohydrates

The digestible and indigestible carbohydrates in our diets have vital functions in our bodies.3,8 These diverse functions are critical to normal metabolism and overall health.

• Expert Perspectives from the Field features examine cutting-edge topics and demonstrate how emerging, and sometimes controversial, research results affect nutrition knowledge and practice.

• Clinical Perspectives highlight the role of nutrition in the prevention and treatment of disease. These topics will be especially interesting to students planning careers in dietetics or health-related fields.

Most of the digestible carbohydrates in our diets are broken down to glucose. As glucose, they provide a primary source of energy, spare protein from use as an energy source, and prevent ketosis.

Providing Energy

• Global Perspectives discuss concepts related to critical health and nutrition issues around the world. These timely features also aim to engage students with thought-provoking challenges.

Preventing Foodborne and Waterborne Illnesses Safe food and water supplies require a “farm-to-fork” approach. All those who grow our food, along with processors, distributors, and consumers, are responsible for food and water safety.64 Several government agencies regulate and coordinate these efforts, monitor food and water, conduct research, enforce wholesomeness and quality standards and laws, and educate consumers (Table 3-8). To do their part, consumers need to know how to handle food safely at home. In

• Historical Perspectives heighten awareness of critical discoveries and events that have affected our understanding of nutritional science.

plete the Take Action:

The main function of glucose is to act as a source of energy for body cells. In fact, red blood cells and cells of the central nervous system derive almost all their energy from glucose. Glucose also fuels muscle cells and other body cells, although many of these cells rely on fatty acids to meet energy needs, especially during rest and light activity. Recall that glucose provides 4 kcal of energy per gram.

• Perspective on the Future features address emerging trends affecting nutrition science and practice.

Sparing Protein from Use as an Energy Source

• Culinary Perspectives focus on interesting food trends and their impact on health.

The amino acids that make up dietary protein are used to build body tissues and to perform other vital functions only when carbohydrate intake provides enough glucose for energy

• Each major heading in the chapters is numbered and cross-referenced to the end-of-chapter summary and study questions to make it easy to locate and prioritize important concepts.

CHAPTER 3 The Food Supply 99

of their diets. In fact, on average, 13% of the sugars. Daily intake is about 335 kcal for men 360 kcal of added sugars per day. beverages to which sugar has been added during added sugar are soft drinks, cakes, cookies, Although sugars supply calories, they usually more nutritious foods. Children and adolescents sugar and empty calories. Dietary surveys indian excess of sugar-sweetened beverages and both of which are essential for bone health. compromise bone development and health. risk of weight gain and obesity. Recent evsugars, particularly sugar-sweetened beverages, adults. The “supersizing” trend noted in food concern. For example, in the 1950s, a typical a 20-ounce bottle is a typical serving. This sugar to the diet. Drinking 1 bottle per day for to 18-pound (7.75 to 8.25 kg) weight gain. also supplies extra energy, which promotes more low fat and fat-free snack products, these added sugar in order to produce a dessert with product often is a high calorie food that equals or fat food product it was designed to replace. (especially fructose) have been associated with condisease—namely, increased blood levels of levels of HDL-cholesterol. Studies also increased consumption of sugar-sweetened bev2 diabetes and Metabolic Syndrome.25 To conclude that increased sugar intake is a risk Metabolic Syndrome. However, it is a good suggested in MyPlate (see Chapter 2).

HISTORICAL PERSPECTIVE

Photographing Atoms

Discovering the molecular layout of biologically important molecules is critical to understanding their function and treating disease. The biochemist and crystallographer Dorothy Crowfoot Hodgkin developed new X-ray techniques that permitted her to determine the structure of over 100 molecules, including insulin, vitamin B-12, vitamin D, and penicillin. Her work with insulin improved treatment of diabetes. Knowing the structure of vitamin B-12 advanced our knowledge of its role in blood health. Learn more about this Nobel Prize winner at www.nobelprize.org/nobel_prizes/ chemistry/laureates/1964/hodgkin-bio.html

Perspective on the Future

hands, workspace, pans, utensils, plates) should be washed thoroughly before preparing the allergen-free meal. Unlike foodborne illness pathogens, such as bacteria and viruses, cooking an allergenic food often does not render its allergens harmless.16

©Digital Vision/Getty Images RF

The prevalence of food allergies has increased in the last 20 years.15,16 Although difficult to estimate, it appears that approximately 5 to 8% of children and 2 to 4% of adults have food allergies.15,16 It is unclear why some people develop allergies and what steps might help decrease the risk of developing food allergies. Most research indicates that maternal dietary restrictions do not play a significant role in preventing food allergies in their children.15 After the child is born, the following steps may help prevent food allergies.9 These guidelines are especially important for families with a history of any type of allergy.

The common wisdom that eating 3500 kcal less than you need will result in the loss of 1 pound has come under great scrutiny. Weight loss research models based on thermodynamics, mathematics, physics, and chemistry indicate many more than 3500 calories may be stored in a pound of body fat. Researchers are working to build and validate more accurate weight loss prediction models.57 Learn more at www.pbrc.edu/research-and-faculty/ calculators/weight-loss-predictor

thinned peanut butter, eggs, milk). If an allergy is diagnosed, children must avoid the problematic foods. For children not at high risk for food allergies, when they are able to tolerate some solid foods (between 4 and 6 months of age), introducing small amounts of potentially allergenic foods may help prevent allergies.17

Many young children with food allergies outgrow them.15,18 Thus, parents should not assume that the allergy will be long-lasting. Allergies to certain foods (e.g., milk, egg, soy, wheat) are more likely to be outgrown than are allergies to other foods (e.g., peanuts, tree nuts, fish, and shellfish).15 Those with allergies may be tested by physicians periodically to determine whether they have outgrown the allergy. If

Perspective from the Field

Spot-reducing by using diet and physical activity is not possible. “Problem” local fat deposits can be reduced in size, however, using lipectomy (surgical removal of fat). This procedure carries some risks and is

Would like to manage weight and healthy food choices in college

Enjoy eating ethnic foods and making them a part of a normal diet

Enjoy eating more vegetables and whole grains compared to animal

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Foodborne illness often means a few hours or even a few days of discomfort and then the illness resolves on its own. In some cases, though, foodborne illness causes more serious medical problems, which can have lifelong effects. High-risk populations—infants and young children, the elderly, pregnant women and their fetuses, and those with impaired immune systems—have the greatest risk of serious complications like these:

These diets teach students how to make better food choices for health and weight management.

These plans and diets help focus on international foods and eating patterns.

These diets encourage consumers to consume more fruits, vegetables, and whole grains to help with weight loss and

How Big Is Your Foo  Print? Growing evidence indicates that what we eat may affect not only

take 10,000 steps/day—typically, we take half that many or less.

Food allergies and food intolerances are not the same. Food allergies cause an immune response as a result of exposure to certain food components, typically proteins. In contrast, food intolerances (see Chapter 4) are caused by an individual’s inability to digest certain food components, usually due to low amounts of specific enzymes. Generally, larger amounts of an offending food are required to produce the symptoms of food intolerance than to trigger allergic symptoms. Food allergies tend to be far more life threatening than food intolerances.

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The American Academy of Allergy and Immunology has a toll-free number (800822-2762) to answer questions about food allergies and help direct people to specialists who treat allergy problems. Free information on food allergies is available by contacting Food Allergy Research & Education at www .foodallergy.org

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Better Digestion by The American Dietetic Association, Leslie Bonci, RD

∙ The College Student’s Guide to Eating Well on Campus by Ann Litt, MS, RD

∙Mediterranean Diet & Pyramid

∙Latino Diet & Pyramid

∙African Diet & Pyramid

∙Asian Diet & Pyramid All at www.oldwayspt.org/

• Hemolytic uremic syndrome (HUS). Most cases of HUS are caused by the toxin produced by Escherichia coli 0157:H7. The toxin attacks red blood cells, causing them to break apart (called hemolysis), and the kidneys, causing waste products to build up (called uremia). Early symptoms of HUS include bloody diarrhea, vomiting, sleepiness, and low urine output. In the worst cases, the toxin damages multiple organs,

Listeriosis Listeria monocytogenes bacteria cause listeriosis, a rare but serious disease. Listeriosis begins with muscle aches, fever, and nausea. It can spread to the nervous system, causing severe headache, stiff neck, loss of balance, and confusion. Pregnant women and their fetuses are particularly vulnerable—listeriosis can cause miscarriage, premature delivery, infection in the fetus, and fetal death. During pregnancy, women are 20 times more likely to develop the disease. The elderly also are susceptible. A 2008 outbreak in Canada from contaminated deli meats resulted in 29 deaths; almost all of them were elderly individuals. About 1 in 5 persons with listeriosis will die from the infection.

∙ Volumetrics Weight-Control Plan by Barbara Rolls, PhD, RD

∙ The Whole Grain Diet Miracle by Lisa Hark, PhD, RD

• Guillain-Barré syndrome (GBS). Campylobacter jejuni is a cause of this rare nervous system disorder. In GBS, peripheral nerves (those that connect the spinal cord and brain to the rest of the body) are

months, and about 30% of those with GBS do not fully recover, experiencing lifelong pain, weakness, and/or paralysis. Reactive arthritis. Foodborne illness caused by Salmonella, Shigella, Campylobacter, and others can cause reactive arthritis. This condition usually develops 2 to 6 weeks after the initial infection and causes inflammation throughout the body, but especially in the joints and eyes. Pain and swelling of the knees, ankles, and feet are common. Inflammation of the urinary tract and blistering of the palms of the hands and soles of the feet also are common. Genetic factors play an important role in determining who develops the disease. Most people with reactive arthritis require medical treatment and will recover after 2 to 6 months, but about 20% experience mild arthritis for a much longer time.

can be continued throughout life. There example, walking vigorously 3 miles tivities of lighter intensity are less likely

tooth decay.
CHAPTER 10 Energy Balance, Weight Control, and

Making Visual Connections

12-3 Food sources of vitamin A.

to MyPlate food groups, used for oils and pink is used for that do not fit easily into food

(e.g., candy, salty snacks).

Publishing /Alamy RF

ChooseMyPlate.gov, U.S. Department of

Adult women RDA = 700

Dynamic, Accurate Artwork

Margarine, 2 tbsp

Beef liver, 3 oz

More than 1000 drawings, photographs, and tables in the text were critically analyzed to identify how each could be enhanced and refined to help students more easily master complex scientific concepts.

Cheddar cheese, 3 oz

Fat-free milk, 1 cup

2.4

Water (70 to 90% of total) Alcohol (80% of total) Bile

• Many illustrations were updated or replaced to inspire student inquiry and comprehension and to promote interest and retention of information.

Sweet potato, 1⁄2 cup

Carrots, 1⁄2 cup

Kale, 1⁄2 cup

Broccoli, 1⁄2 cup

Spinach, 1⁄2 cup

Romaine lettuce, 1⁄2 cup

Vitamin K and biotin (synthesized by microorganisms in the large intestine) Gases Water (10 to 30% of total)

• Many illustrations were redesigned to use brighter colors and a more attractive, contemporary style. Others were fine-tuned to make them clearer and easier to follow. Navigational aids show where a function occurs and put it in perspective of the whole body.

• Coordinated color schemes and drawing styles keep presentations consistent and strengthen the educational value of the artwork. Color-coding and directional arrows in figures make it easier to follow events and reinforce interrelationships.

Acorn squash, 1⁄2 cup

Apricot, 1⁄2 cup

Mango, 1⁄2 cup

Figure 4-17 Nutrient absorption relies on 4 major absorptive processes. 1 Passive diffusion (in green) is diffusion of nutrients across the absorptive cell membranes.

Peach, 1⁄2 cup

Dietary Guidelines for Americans 2015–2020

and several proteases (to digest protein). Pancreatic en zymes break large macronutrient molecules into smaller subunits.

2 Facilitated diffusion (in blue) uses a carrier protein to move nutrients down a concentration gradient. 3 Active absorption (in red) involves a carrier protein as well as energy to move nutrients (against a concentration gradient) into absorptive cells.

Gastrointestinal Hormones: A Key to Orchestrating Digestion

4 Phagocytosis and pinocytosis (in gray and orange) are forms of active transport in which the absorptive cell membrane forms an invagination that engulfs a nutrient to bring it into the cell.

The diets of many people in the U.S. and Canada are too high in calories, fat, saturated fat, trans fat, cholesterol, sugar, salt, and alcohol.17 Many consume insufficient amounts of whole grains, fruits, and vegetables. These dietary patterns put many of us at risk of major chronic “killer” diseases, such as cardiovascular disease and cancer. In response to concerns about the prevalence of these killer disease patterns, every 5 years since 1980, the U.S. Department of Agriculture (USDA) and U.S. Department of Health and Human Services (DHHS) have published the Dietary Guidelines for Americans (Dietary Guidelines, for short).

The Dietary Guidelines are the foundation of the U.S. government’s nutrition policy and education. They reflect what scientific experts believe is the most accurate and up-to-date scientific knowledge about nutritious diets, physical activity, and related healthy lifestyle choices.

The Dietary Guidelines are designed to meet nutrient needs while reducing the risk of obesity, hypertension, cardiovascular disease, type 2 diabetes, osteoporosis, alcoholism, and foodborne illness. The Dietary Guidelines also guide government nutrition programs, research, food labeling, and nutrition education and promotion. For example, the Dietary Guidelines provide

RE was based on the assumption that carotenoids made a greater contribution to vitamin A needs than is now known to be the case. Nutrient databases may contain this older RE standard because it will take some time to update these resources.

The remarkable work of the digestive system requires the careful regulation and coordination of several processes, including the production and release of hormones throughout the length of the GI tract. Five hormones, part of the endocrine system, play key roles in this regulation: gastrin, secretin, cholecystokinin (CCK), somatostatin, insulinotropic peptide (Table 4-4). To illustrate their functions, let’s follow a turkey sandwich through the digestive system:

and dietary supplements may be useful sources of 1 or more nutrients that otherwise might be consumed in less than recommended amounts. These practices are especially important for people whose typical food choices lead to a diet that cannot meet nutrient recommendations such as for calcium. However, dietary supplements are not a substitute for a healthful diet.

Figure 4-15 The common bile duct from the liver and gallbladder and the pancreatic duct join together at the hepatopancreatic sphincter to deliver bile, pancreatic enzymes, and bicarbonate to

The Dietary Guidelines for Americans 2015–2020 have 5 key recommendations intended to help people age 2 and older, as well as special population groups (e.g., older adults), achieve healthy eating patterns. The key recommendations have interconnected relationships; thus, all need to be implemented to achieve the best health.

To compare the older RE or IU standards with current RAE recommendations, assume that, for any preformed vitamin A in a food or added to food, 1 RE (3.3 IU) = 1 RAE. There is no easy way to convert RE or IU units to RAE units for foods that naturally contain provitamin A carotenoids. A general rule of thumb is to divide the older values for foods containing carotenoids by 2, and then do the conversion from RE to IU to RAE, as shown in Table 12-1. There also is no easy way to do this calculation for food containing a mixture of preformed vitamin A and carotenoids. Generally speaking, these foods contain less vitamin A than the RE or IU values suggest.

Individuals should aim to meet their

Vitamin A Needs

1. As you eat a turkey sandwich (or even just think about it), gastrin is produced by cells in the stomach. Gastrin signals other stomach cells to release HCl and pepsinogen (for protein digestion). After thorough mixing, the turkey sandwich, now liquid chyme, is released in small amounts into the small intestine.

As chyme is gradually released from the stomach into the small intestine, gastrin production slows and the small intestine secretes secretin and CCK. Both hormones trigger the release of enzyme- and bicarbonate-containing pancreatic juices that digest carbohydrate, fat, and protein and reduce the acidity of the intestinal contents. Fat in the small intestine (from the mayonnaise and the turkey) further stimulates the secretion of CCK by the small intestine. CCK promotes contraction of the gallbladder, which releases the stored bile that aids fat digestion. Relaxation of the hepatopancreatic sphincter allows bile and pancreatic juices to flow into the small intestine. CCK also slows GI motility to give digestive enzymes from the small intestine and pancreas

The RDA for vitamin A is 900 μg Retinol Activity Equivalents (RAE) per day for adult men and 700 μg RAE per day for adult women.2 At this intake, adequate body stores of vitamin A are maintained in healthy adults. The Daily Value used on food packages and supplements is 900 μg. At present, there is no DRI for beta-carotene or any of the other provitamin A carotenoids.1 The average intakes of adult men and women in North America currently meet DRI guidelines for vitamin A. Thus, vitamin A is no longer a mandatory nutrient to include on food and supplement labels.

Elise is a 20-year-old college sophomore. Over the last few months, she has been experiencing regular bouts of esophageal burning, pain, and a sour taste in the back of her mouth. This usually happens after a large lunch or dinner. Elise often takes an over-the-counter antacid to relieve these unpleasant symptoms. However, the symptoms have worsened and Elise has decided to visit the university health center. The nurse practitioner at the center tells Elise it is good she came in for a checkup because she suspects Elise is experiencing heartburn and acid indigestion, but she might also be experiencing gastroesophageal reflux disease (GERD). What types of lifestyle and dietary changes may help reduce or prevent heartburn and GERD? What types of medications are especially helpful in treating this problem?

• In many figures, process descriptions appear in the body of the figure. This pairing of the action and an explanation walks students step-by-step through the process and increases the teaching effectiveness of these figures.

• Intriguing chapter opening photos pique students’ curiosity by featuring seemingly unrelated topics that draw connections between the photo and nutrition.

4

• Finally, a careful comparison of artwork with its corresponding text was done to ensure that they are completely coordinated and consistent. The final result is a striking visual program that holds readers’ attention and supports the goals of clarity, ease of comprehension, and critical thinking. The attractive layout and design of this edition are clean, bright, and inviting. This creative presentation of the material is geared toward engaging today’s visually oriented students.

Illustrative Chapter Summary

The visual chapter summary continues to reinforce key concepts and promote student engagement and comprehension.

4.2

Sphincters along the GI tract control the flow of its contents. The accessory organs (liver, gallbladder, and pancreas) are an important part of the digestive system. Movement through the GI tract is mainly through muscular contractions known as peristalsis. GI contents are mixed with segmental contractions. Enzymes are specialized protein molecules that speed up digestion by catalyzing chemical reactions. Most digestive enzymes are synthesized in the small intestine and pancreas. A lack of digestive enzymes can result in poor digestion, poor absorption, malnutrition, and weight loss.

4.3 Chewing food breaks it into small pieces and increases its surface area, which enhances enzyme activity. Amylase produced by salivary glands digests a small amount of starch. Chewed food mixed with saliva is called a bolus. When swallowing is initiated, the epiglottis covers the trachea to prevent food from entering it. Peristalsis moves food down the esophagus. There are 5 basic taste sensations perceived by taste cells on taste buds in the mouth, especially the tongue. Genetic variability affects the ability to taste bitter compounds. The sense of smell contributes greatly to flavor perceptions.

4.4 The lower esophageal sphincter protects the esophagus from the backflow of acidic stomach contents. When this sphincter does not work normally, heartburn and GERD may occur. Stomach cells produce gastric juice (HCl, pepsinogen, mucus, and intrinsic factor). The hormone ghrelin triggers hunger and eating. Pepsin (from pepsinogen) starts the digestion of protein. Mixing of food and gastric juice results in the production of chyme, the liquid substance released in small amounts into the small intestine.

4.5 The small intestine has 3 sections: duodenum, jejunum, and ileum.  Most digestion occurs in the small intestine.

Connecting with the Latest Updates

Global Updates and Changes

΅ The entire eleventh edition has been updated, refined, and streamlined to enhance learning.

΅ Complete Nutrition Facts panel updated to include latest regulations

΅ Incorporation of new Daily Values in charts demonstrating nutrient content

΅ New Culinary Perspective feature throughout the eleventh edition

΅ All Dietary Reference Intakes (RDA, AI, UL, EAR, and AMDR) grouped into 1 appendix for quick and easy access

Chapter 1, The Science of Nutrition

΅ Updated statistics on leading causes of death

΅ Fresh, new photos for visual engagement

΅ Section introducing how to navigate scientific journal articles to enhance student self-confidence in using these materials

΅ New FDA guidance to the dietary supplement industry introduced

Chapter 2, Tools of a Healthy Diet

΅ Complete Nutrition Facts panel updated to include latest regulations

΅ Application of Dietary Reference Intakes (DRIs) to federal nutrition programs incorporated

΅ Extensive revision of Table 2-2 to include the newly released Daily Value (DV) updates

΅ All images of the Nutrition Facts panel replaced to show the new format

΅ Updated coverage of the new restaurant menu labeling regulations

΅ Figure summarizing the Dietary Guidelines for Americans (Figure 2-6) refined to facilitate reading ease and comprehension.

΅ Incorporated most recent updates to MyPlate that were made based on the Dietary Guidelines for Americans 2015–2020

΅ Added latest guidance on added sugar maximums (Table 2-6)

Chapter 3, The Food Supply

΅ Updated domestic and international food insecurity statistics highlighting the worldwide burden of malnutrition and hunger

΅ Enhanced discussion on food deserts

΅ Addition of the effects of the Syrian civil war on food insecurity

΅ New discussion of the impact of food waste on global food insecurity

΅ Expanded discussion of the nutritional benefits of foods grown using conventional vs. organic farming practices

΅ Extensive revision of discussion of biotechnology, genetically modified foods and animals, production methods (such as gene editing), regulations, and safety

΅ New example of how intentional food additives are used in typically consumed foods

΅ Enhanced discussion of safety concerns associated with incidental additives, such as arsenic, pesticide residues, and BPA

΅ Latest CDC foodborne illness statistics included

΅ Updates to foodborne illness food sources, symptoms, and transmission incorporated into key chapter tables (Tables 3-4, 3-5, 3-6, and 3-7)

΅ Fully updated discussion of prions

΅ Discussion of water contamination in Flint, Michigan, added

΅ Overhauled discussion of lead poisoning

΅ New section on arsenic in the food supply and the contributions of rice

΅ Extensive revision of discussion of polychlorinated biphenyls (PCBs) in the food supply

΅ New table (Table 3-9) summarizing guidelines to help children and pregnant and breastfeeding women limit mercury in the diet

΅ New Expert Perspective from the Field on sustainability in university food service

Chapter 4, Human Digestion and Absorption

΅ Enhanced discussion on taste perception, super tasters, and PROP

΅ Added explanation of the functions of the stomach during digestion and incorporated it into Table 4-4 as a regulatory hormone of the GI tract

΅ Incorporated role of ghrelin in regulation of food intake

΅ Update of the Global Perspective to include latest global data on child death from diarrhea

΅ Extensive revision of gut microbiota section to incorporate the latest discoveries in this rapidly changing area of scientific study

΅ Discussion of probiotics and prebiotics expanded

΅ New Culinary Perspective featuring fermented foods

΅ Low FODMAP diet introduced

΅ New section on nonalcoholic fatty liver disease exploring this increasingly common disorder

Chapter 5, Carbohydrates

΅ New photo of stevia added

΅ Take Action revised to increase student engagement

΅ Statistics on carbohydrate and sugar consumption revised

΅ Figures updated to show the newest Nutrition Facts panels

΅ Role of whole grains in reducing obesity risk, enhancing blood glucose control, and reducing cholesterol absorption added

΅ Extensive revision of Figure 5-17 to enhance student understanding of blood glucose regulation

Chapter 6, Lipids

΅ Triglyceride section headers refined to increase clarity

΅ Enhanced labeling of type and health effects of fatty acids (Table 6-1)

΅ Refined figure of adipose cell importing triglycerides

΅ Streamlined discussion body fat’s role in insulating the body

΅ Updated saturated fat intakes to Institute of Medicine recommendations

΅ Discussion of saturated fat intake revised to reflect recent research findings and expert guidance

΅ Figure 6-17 caption refined to promoting increased comprehension of differences in lipoprotein structure and composition

Chapter 7, Proteins

΅ New discussion on pulses as a key component of vegetarian diets and as sustainable crops

΅ Enhanced image of normal and sickle red blood cells

΅ New Knowledge Check items for sources of protein

΅ Refined fluid balance depiction (Figure 7-14) to enhance clarity

΅ Latest statistics on protein-energy malnutrition incorporated

΅ Revised food allergy prevention discussion to reflect the latest guidance

΅ Updated Global Perspective to reflect most current population projections

Chapter 8, Alcohol

΅ Alcohol standard sizes updated to use alcoholic drink equivalents

΅ Addition of equation demonstrating calculation of alcohol drink equivalents

΅ Terminology updated to use DSM-5 recommendations of “alcohol use disorder”

΅ Alcohol consumption trends and statistics updated

΅ New Culinary Perspective explores cooking with alcohol and alcohol burn-off and retention by food preparation method

΅ Newly available powdered alcohol described

΅ New section on college and underage drinking included

΅ Extensive revision of table on the impact of harmful and underage college drinking (Table 8-4)

΅ Dangers of combining alcohol and caffeine added

΅ Updated cirrhosis section to reflect newest research

΅ New table summarizing DSM-5 diagnostic criteria for an alcohol use disorder added

΅ Enhanced discussion of ethnicity and alcohol abuse

΅ New section on economic costs of alcohol abuse included

΅ Streamlined Clinical Perspective to focus on treatment of alcohol use disorders

΅ Improved labeling of figure showing carnitine shuttling fatty acids into mitochondria (Figure 9-12)

΅ New figure illustrating the J-shaped relation between alcohol intake and health risks

΅ Statistics on fetal alcohol spectrum disorders updated

Chapter 9, Energy Metabolism

΅ Improved clarity of image explaining ATP structure (Figure 9-3)

΅ Refined image depicting ATP storing and yielding energy (Figure 9-4)

΅ Enhanced visual quality of figure demonstrating aerobic carbohydrate metabolism (Figure 9-5)

΅ Improved explanatory aspects of image explaining glycolysis (Figure 9-7)

΅ Modified alcohol metabolism figure to enhance student understanding (Figure 9-19)

΅ New Critical Thinking added

΅ Revised Knowledge Check items to promote learning

΅ Refined visual summary of the liver’s role in metabolism (Figure 9-21)

Chapter 10, Energy Balance, Weight Control, and Eating Disorders

΅ Most up-to-date map of obesity rates in the U.S.

΅ Latest statistics on high fructose corn syrup consumption added

΅ Addition of sleep deprivation as a factor influencing hunger feelings

΅ Newest fad diets incorporated into Table 10-7

΅ New headings added to guide study of eating behavior regulation

΅ Newest statistics on prevalence and susceptibility of disordered eating

΅ Eating disorders section enhanced to describe types of anorexia nervosa

΅ Section on binge eating disorder added

΅ Other Specified Feeding and Eating Disorders updated and expanded to reflect latest diagnostic criteria (DSM-5)

Chapter 11, Nutrition, Exercise, and Sports

΅ Section added on Relative Energy Deficiency in Sport (REDS)

΅ Updated procedures for cooling the body when heat exhaustion occurs

΅ Latest recommendations for use of sports drinks incorporated

Chapter 12, The Fat-Soluble Vitamins

΅ Updated food sources of vitamin A (Figure 12-3) to reflect latest Daily Values

΅ Nutrition Facts labeling changes for vitamin A incorporated

΅ Links noted between beta-carotene and alpha-carotene’s role in breast cancer risk reduction from the European Prospective Investigation into Cancer (EPIC) and Nurses’ Health Study discussed

΅ Expanded discussion on possible links between betacarotene, lycopene, and lutein and cardiovascular disease risk reduction

΅ New data on vitamin A deficiency in Global Perspective

΅ Newest Daily Values incorporated into food sources of vitamin D (Figure 12-11)

΅ Streamlined discussion of vitamin D needs, toxicity, and concerns

΅ Latest Daily Values for vitamin E included in food sources (Figure 12-16)

΅ Discussion of latest vitamin E research related to cancer added

΅ Vitamin K food sources revised to reflect newest Daily Values (Figure 12-20)

΅ Case Study updated to reflect newly released Daily Values

Chapter 13, The Water-Soluble Vitamins

΅ Water-soluble vitamin intakes, prominent food sources, and the prevalence of inadequate intake statistics updated

΅ Expanded vitamin functions to address 1 carbon metabolism (Figure 13-1)

΅ New section on B-vitamins and epigenetics

΅ Streamlined discussion on thiamin discovery, transketolase coenzyme function, and deficiency

΅ Thiamin food sources updated to reflect latest Daily Values (Figure 13-6)

΅ Newest Daily Values incorporated into food sources of riboflavin (Figure 13-7)

΅ Updated food sources of niacin (Figure 13-9) to reflect latest Daily Values

΅ Refined discussion of niacin absorption, transport, storage, and excretion

΅ Extensive update of pharmacologic use of niacin

΅ Latest Daily Values for pantothenic acid included in food sources (Figure 13-12)

΅ Figure depicting food sources of biotin updated with most recent Daily Values (Figure 13-13)

΅ Expanded discussion of risks associated with high homocysteine blood concentrations

΅ Vitamin B-6 food sources incorporate latest Daily Values (Figure 13-14)

΅ Updated information on the pharmacologic use of vitamin B-6

΅ Refined presentation of folate in foods and updated with latest Daily Values (Figure 13-16)

΅ New Culinary Perspective on beans, lentils, and dried peas

΅ Food sources of vitamin B-12 revised to reference recently released Daily Values (Figure 13-19)

΅ Extensive revision of choline functions

΅ Streamlined discussion of vitamin C sources and updated to newest Daily Values (Figure 13-23)

΅ Enhanced presentation of vitamin C’s function as an antioxidant

΅ New case studies of recent scurvy cases incorporated

΅ Condensed material by excluding discussion of vitamin-like compounds

Chapter 14, Water and Major Minerals

΅ Enhanced figure to feature water’s role in many processes in the body (Figure 14-1)

΅ Streamlined description of functions of water

΅ Refined sources of water discussion

΅ Updated presentation of dehydration and water intoxication

΅ Focused presentation of overall mineral deficiencies on Dietary Guidelines for Americans

΅ Latest statistics on major mineral intakes, prominent food sources, and the prevalence of inadequate intake included

΅ Food sources of sodium revised to reference recently released Daily Values (Figure 14-12)

΅ Streamlined presentation of excess sodium intake and Upper Level to maximize clarity

΅ New Culinary Perspective on specialty and sea salt

΅ Updated food sources of potassium to include newest Daily Value (Figure 14-14)

΅ Refined presentation of hypertension risk factors

΅ Updated food sources of calcium (Figure 14-15) to reflect latest Daily Value

΅ Reorganized calcium supplements discussion to enhance understanding

΅ Streamlined presentation of factors increasing osteoporosis risk (Table 14-11)

΅ Latest Daily Values for phosphorus included in food sources (Figure 14-26)

΅ Magnesium food sources incorporate most recently released Daily Values (Figure 14-27)

Chapter 15, Trace Minerals

΅ Food sources of zinc revised to reference recently released Daily Values (Figure 15-18)

΅ Figure depicting food sources of copper updated with most recent Daily Values (Figure 15-11)

΅ Manganese food sources incorporate latest Daily Values (Figure 15-13)

΅ Updated food sources of selenium to include newest Daily Value (Figure 15-17)

΅ Latest fluoridated water statistics for the U.S. added (Figure 15-20)

΅ Enhanced Take Action focusing on fluoridation

΅ Refined Clinical Perspective on nutrients, diet, and cancer to reflect newest research and recommendations

΅ Latest statistics on cancer deaths incorporated (Figure 15-21)

Chapter 16, Nutritional Aspects of Pregnancy and Breastfeeding

΅ Expert Perspective from the Field updated to include fortification of masa corn meal

΅ Updated pregnancy and malnutrition statistics

΅ Smoking during pregnancy and breastfeeding expanded to include nicotine from cigarettes, electronic cigarettes, and patches

΅ Dietary intake of breastfeeding women with regard to potential allergens updated

΅ Added advice from the CDC for breastfeeding by women with HIV

Chapter 17, Nutrition during the Growing Years

΅ Updated guidance on cholesterol screening for children

΅ New section on potassium needs during the growing years

΅ New breastfeeding statistics added

΅ Updated table describing advantages to infants provided by human milk (Table 17-2)

΅ Expanded discussion of physical abilities indicating infants’ readiness for solid foods

΅ Complete overhaul of Figure 17-5 describing the latest infant feeding guidelines from the American Academy of Pediatrics

΅ American Academy of Pediatrics whole diet approach and children’s diet incorporated

΅ Added American Academy of Pediatrics guidelines for parents of toddlers

΅ New school wellness policy legislation reviewed

΅ Hyperactivity section updated

Chapter 18, Nutrition during the Adult Years

΅ Updated statistics and figure (Figure 18-1) summarizing life expectancy

΅ Table summarizing current hypotheses about the causes of aging (Table 18-1) updated and enhanced

΅ Potassium as a nutrient of concern for adults added

΅ Role of increased protein intake as potential strategy for reducing risk of sarcopenia introduced

΅ Current chronic disease prevalence rates incorporated

΅ Revised Clinical Perspective to reflect newest categorization of complementary and alternative health approaches

΅ Streamlined table summarizing popular herbal remedies (Table 18-6)

Acknowledgments

We offer a hearty and profound thank you to the many individuals who have supported and guided us along the way.

To our loved ones: Without your patience, understanding, assistance, and encouragement, this work would not have been possible.

To our wonderful students—past, present, and future: The lessons you have taught us over the years have enlightened us and sustained our desire to provide newer, better opportunities to help you successfully launch your careers and promote healthful lifelong living. Thank you in particular to the students who have used SmartBook®, as your feedback was instrumental in the revisions for this edition.

To our amazing team at McGraw-Hill Education: Senior Portfolio Manager Marija Magner and Senior Product Developer Michelle Flomenhoft—we thank you most of all for your confidence in us! We deeply appreciate your endless encouragement and patience as you expertly shepherded us along the way. A special thanks to Vice President, Portfolio and Learning Content Mike Ryan, Managing Director Thomas Timp, Marketing Manager Valerie Kramer and the entire marketing team. Sincere thanks to Content Project Managers Sandy Wille and Jessica Portz for keeping production on track, Designer Tara McDermott, and Copy Editor Debra DeBord for her meticulous attention to detail. We also thank Content Licensing Specialist Shawntel Schmitt, and the many talented illustrators and photographers for their expert assistance.

To our conscientious, dedicated expert reviewers and instructors: Thank you for sharing your insightful and constructive comments with us. We truly appreciate the time you committed to reviewing this book and discussing your thoughts and goals for this course. We especially appreciate the assistance provided by Stephanie Atkinson, Kelly Brownell, Clare M. Hasler-Lewis, Penny Kris-Etherton, Cynthia Kupper, Judith Rodriguez, Kristi Theisen, and Margo G. Wootan, those who shared their expertise in compiling the Expert Perspective from the Field features. Your suggestions and contributions clearly reflect dedication to excellence in teaching and student learning and are invaluable to this edition.

To Your Health!

Carol Byrd-Bredbenner

Gaile Moe

Jacqueline Berning

Danita Kelley

Meet the Author Team iv Preface v

Part 1 Nutrition

Fundamentals 3

1 THE SCIENCE OF NUTRITION 3

1.1 Nutrition Overview 4

Nutrients 4

Phytochemicals and Zoochemicals 8

Expert Perspective from the Field: Functional Foods 9

1.2 Energy Sources and Uses 10

1.3 The North American Diet 12

What Influences Our Food Choices? 13

Take Action: Why You Eat What You Do 14

Global Perspective: The Price of Food 15

1.4 Nutritional Health Status 16

Health Objectives for the U.S. for the Year 2020 16

Assessing Nutritional Status 17

Limitations of Nutritional Assessment 18

Importance of Being Concerned about Nutritional Status 19

Getting Nutrition-Related Advice: The Nutrition Care Process 19

Clinical Perspective: Genetics and Nutrition 21

Take Action: Create Your Family Tree for Health-Related Concerns 24

1.5 Using Scientific Research to Determine Nutrient Needs 24

Making Observations and Generating Hypotheses 25

Laboratory Animal Experiments Human Experiments 27

1.6 Evaluating Nutrition Claims and Products 31

Buying Nutrition-Related Products 31

Chapter Summary 33

Study Questions 35

References 37

2 TOOLS OF A HEALTHY DIET 39

2.1

Dietary Reference Intakes (DRIs) 40

Estimated Average Requirements (EARs) 40

Recommended Dietary Allowances (RDAs) 41

Adequate Intakes (AIs) 42

Tolerable Upper Intake Levels (Upper Levels, or ULs) 42

Estimated Energy Requirements (EERs) 42

Acceptable Macronutrient Distribution Ranges (AMDRs) 43

Appropriate Uses of the DRIs 43

Putting the DRIs into Action to Determine the Nutrient Density of Foods 44

2.2 Daily Values (DVs) 45

Reference Daily Intakes (RDIs) 45

Daily Reference Values (DRVs) 45

Putting the Daily Values into Action on Nutrition Facts Panels 47

Take Action: Applying the Nutrition Facts Label to Your Daily Food Choices 52

Global Perspective: Front-of-Package Nutrition Labeling 53

2.3 Nutrient Composition of Foods 53

Putting Nutrient Databases into Action to Determine Energy Density and Dietary Intake 54

Expert Perspective from the Field: Menu Labeling: How Many Calories Are in That? 55

2.4 Dietary Guidelines for Americans 2015–2020 56

Putting the Dietary Guidelines into Action 58

Take Action: Are You Putting the Dietary Guidelines into Practice? 60

2.5 MyPlate 60

Putting MyPlate into Action 61

Rating Your Current Diet 66

Take Action: Does Your Diet Meet MyPlate Recommendations? 67

Chapter Summary 68

Study Questions 70

References 71

THE FOOD SUPPLY 73

3.1

Food Availability and Access 74

Health Consequences of Malnutrition and Food Insecurity 74

Food Insecurity in the U.S. 75

Programs to Increase Food Security in the U.S. 76

Food Insecurity and Malnutrition in the World’s Developing Regions 78

3.2 Food Production 79

Organic Foods 79

Biotechnology—Genetically Modified Foods 80

3.3 Food Preservation and Processing 84

Food Irradiation 84

Food Additives 84

3.4

Food and Water Safety 87

Foodborne Illness Overview 87

Take Action: A Closer Look at Food Additives 88

Microbial Pathogens 89

Water Safety 98

Preventing Foodborne and Waterborne Illnesses 99

Clinical Perspective: Foodborne Illness Can Be Deadly 101

Take Action: Check Your Food Safety Skills 102

3.5 Environmental Contaminants in Foods 103

Lead 103

Arsenic 104

Dioxins and Polychlorinated Biphenyls (PCBs) 104

Mercury 104

Pesticides and Antibiotics 104

Global Perspective: Traveler’s Diarrhea 106

Expert Perspective from the Field: Sustainability in University Food Service 109

Chapter Summary 110

Study Questions 112

References 114

4

HUMAN DIGESTION AND ABSORPTION 117

4.1 Organization of the Human Body 118

4.2 Digestive System Overview 122

Anatomy of the GI Tract 123

GI Motility: Mixing and Propulsion 124

Digestive Enzymes and Other Secretions 124

4.3 Moving through the GI Tract: Mouth and Esophagus 126

Taste and Smell 126

Swallowing 127

4.4 Moving through the GI Tract: Stomach 128

4.5 Moving through the GI Tract: Small

Intestine and Accessory Organs 130

Liver, Gallbladder, and Pancreas 131

Gastrointestinal Hormones: A Key to Orchestrating Digestion 132

Absorption in the Small Intestine 133

Global Perspective: Diarrhea in Infants and Children 135

4.6 Moving Nutrients around the Body:

Circulatory Systems 136

Cardiovascular System 137

Lymphatic System 137

4.7 Moving through the GI Tract: Large Intestine 137

Gut Microbiota 138

Culinary Perspective: Fermented Foods 140

Absorption of Water and Electrolytes 140

Elimination of Feces 141

4.8 When Digestive Processes Go Awry 141

Heartburn and Gastroesophageal Reflux Disease 141

Ulcers 142

Nonalcoholic Fatty Liver Disease 143

Gallstones 144

Food Intolerances 144

Intestinal Gas 144

Constipation 145

Diarrhea 146

Clinical Perspective 147

Irritable Bowel Syndrome 147

Take Action: Investigate Flours and Grains for Gluten Content 147

Expert Perspective from the Field: Glutenrelated Disorders: Celiac Disease and Nonceliac Gluten Sensitivity 148

Inflammatory Bowel Disease 149

Hemorrhoids 149

Take Action: Are You Eating for a Healthy Digestive System? 150

Chapter Summary 151

Study Questions 153

References 154

Part 2 Energy-Yielding

Nutrients and Alcohol 157

5 CARBOHYDRATES 157

5.1 Structures of Carbohydrates 158

Monosaccharides: Glucose, Fructose, Galactose, Sugar Alcohols, and Pentoses 158

Disaccharides: Maltose, Sucrose, and Lactose 160

Oligosaccharides: Raffinose and Stachyose 161

Polysaccharides: Starch, Glycogen, and Fiber 161

5.2 Carbohydrates in Foods 164

Starch 165

Fiber 165

Nutritive Sweeteners 165

Non-nutritive (Alternative) Sweeteners 167

Take Action: Choosing a Sandwich 169

5.3 Recommended Intake of Carbohydrates 169

Our Carbohydrate Intake 170

Take Action: Estimate Your Fiber Intake 173

5.4 Functions of Carbohydrates in the Body 173

Digestible Carbohydrates 173

Indigestible Carbohydrates 174

5.5 Carbohydrate Digestion and Absorption 176

Digestion 176

Absorption 177

Expert Perspective from the Field: Taxing Sugar-Sweetened Beverages 178

5.6 Health Concerns Related to Carbohydrate Intake 179

Very-High-Fiber Diets 179

High Sugar Diets 179

Lactose Intolerance 180

Glucose Intolerance 180

Clinical Perspective: Diabetes Mellitus 183

Glycemic Index and Glycemic Load 186

Chapter Summary 188

Study Questions 190

References 191

6 LIPIDS 193

6.1 Triglycerides 194

Structure 194

Naming Fatty Acids 196

Essential Fatty Acids 197

6.2 Food Sources of Triglycerides 198

Hidden Fats 200

Fat Replacements 200

Take Action: Is Your Diet High in Saturated and Trans Fat? 201

6.3 Functions of Triglycerides 202

Provide Energy 202

Provide Compact Energy Storage 202

Insulate and Protect the Body 202

Aid Fat-Soluble Vitamin Absorption and Transport 203

Essential Fatty Acid Functions 203

6.4 Phospholipids 204

Phospholipid Functions 204

Sources of Phospholipids 205

6.5 Sterols 206

Sterol Functions 206

Sources of Sterols 206

6.6 Recommended Fat Intakes 207

Mediterranean Diet 208

Essential Fatty Acid Needs 208

Our Fat Intake 208

6.7

Fat Digestion and Absorption 209 Digestion 209

©D. Hurst/Alamy

6.8

Transporting Lipids in the Blood 212

Transporting Dietary Lipids Utilizes Chylomicrons 212

Transporting Lipids Mostly Made by the Body Utilizes Very-Low-Density Lipoproteins 214

LDL Removal from the Blood 215

HDL’s Role in Removing Blood LDL 215

6.9 Health Concerns Related to Fat

Intake 216

High Polyunsaturated Fat Intake 216

Excessive Omega-3 Fatty Acid Intake 216

Imbalances in Omega-3 and Omega-6 Fatty Acids 216

Intake of Rancid Fats 216

Expert Perspective from the Field: Omega-6

Fatty Acids: Harmful or Healthful? 217

Clinical Perspective: Cardiovascular Disease (CVD) 218

Diets High in Trans Fat 220

Diets High in Total Fat 221

Take Action: What Is Your 10-Year Risk of Cardiovascular Disease? 222

Chapter Summary 224

Study Questions 226

References 227

7 PROTEINS 229

7.1 Structure of Proteins 230

Amino Acids 230

Synthesis of Nonessential Amino Acids 231

Amino Acid Composition: Complete and Incomplete Proteins 232

7.2 Synthesis of Proteins 233

Transcription and Translation of Genetic Information 233

Protein Organization 235

Denaturation of Proteins 236

Adaptation of Protein Synthesis to Changing Conditions 236

7.3 Sources of Protein 236

Evaluation of Food Protein Quality 237

7.4 Nitrogen Balance 240

Recommended Intakes of Protein 240

Take Action: Meeting Protein Needs When

Dieting to Lose Weight 242

7.5 Protein Digestion and Absorption 242

7.6 Functions of Proteins 244

Producing Vital Body Structures 245

Maintaining Fluid Balance 245

Contributing to Acid-Base Balance 246

Forming Hormones, Enzymes, and Neurotransmitters 247

Contributing to Immune Function 247

Transporting Nutrients 247

Forming Glucose 247

Expert Perspective from the Field: Nutrition and Immunity 248

Providing Energy 249

7.7 Health Concerns Related to Protein Intake 249

Protein-Energy Malnutrition 249

High Protein Diets 251

Clinical Perspective: Food Protein Allergies 252

Global Perspective: How Big Is Your Food Print? 253

7.8 Vegetarian Diets 254

Take Action: Protein and the Vegan 256

Special Concerns for Infants and Children 257

Chapter Summary 258

Study Questions 260 References 261

8 ALCOHOL 263

8.1 Sources of Alcohol 264

Production of Alcoholic Beverages 265

Culinary Perspective: Cooking with Alcohol 266

8.2 Alcohol Absorption and Metabolism 267

Alcohol Metabolism: 3 Pathways 267

8.3 Alcohol Consumption 270

College and Underage Drinking 270

Take Action: Alcohol and Driving 271

8.4 Health Effects of Alcohol 271

Guidance for Using Alcohol Safely 272

Potential Benefits of Alcohol Intake 272

Risks of Excessive Alcohol Intake 273

Effects of Alcohol Abuse on Nutritional Status 275

Alcohol Consumption during Pregnancy and Breastfeeding 276

Global Perspective: Alcohol Intake around the World 277

8.5 Alcohol Use Disorders  278

Genetic Influences 278

Effect of Gender 279

Age of Onset of Drinking 279

Ethnicity and Alcohol Use 279

Mental Health and Alcohol Use 280

The Economic Costs of Alcohol Abuse  280

Clinical Perspective: Treatment of Alcohol Use Disorders 281

Take Action: Do You Know Why These Are Alcohol Myths? 282

Chapter Summary 283

Study Questions 285 References 286

Part 3 Metabolism and Energy Balance 289

9 ENERGY METABOLISM 289

9.1 Metabolism: Chemical Reactions in the Body 290

Converting Food into Energy 290

Oxidation-Reduction Reactions: Key Processes in Energy Metabolism 292

9.2 ATP Production from Carbohydrates 293 Glycolysis 294

Transition Reaction: Synthesis of Acetyl-CoA 294 Citric Acid Cycle 296

Disposal of Excess Amino Groups from Amino Acid Metabolism 305

Global Perspective: Cancer Cell Metabolism 306

9.5 Alcohol Metabolism 307

9.6 Regulation of Energy Metabolism 308 The Liver 310

ATP Concentrations 310

Enzymes, Hormones, Vitamins, and Minerals 310

9.7 Fasting and Feasting 311

Fasting 311

Feasting 312

Take Action: Weight Loss and Metabolism 314

Clinical Perspective: Inborn Errors of Metabolism 315

Take Action: Newborn Screening in Your State 316

Chapter Summary 317

Study Questions 319 References 320

10 ENERGY BALANCE, WEIGHT CONTROL, AND EATING DISORDERS 323

10.1 Energy Balance 324 Energy Intake 325

Energy Expenditure 326

10.2 Measuring Energy Expenditure 328

10.3 Eating Behavior Regulation 330 Estimating Body Weight and

Measuring Body Fat Content 332 Assessing Body Fat Distribution 334 Factors Affecting Body Weight and 337

Genetic and Environmental 338

Treatment of Overweight and Control of Energy Intake 341

Regular Physical Activity 341

Control of Problem Behaviors 343

Expert Perspective from the Field: Tailoring a Healthy Eating Plan to Fit

346

©Michael Simons/123RF

10.7 Fad Diets 346

Clinical Perspective: Professional Help for Weight Control 350

Take Action: Changing for the Better 352 10.8

Eating Disorders 354

Prevalence and Susceptibility 354

Anorexia Nervosa 355

Bulimia Nervosa 358

Binge Eating Disorder 360

Other Specified Feeding and Eating Disorders (OSFED) 361

Other Related Conditions 362

Prevention of Eating Disorders 362

Take Action: Assessing Risk of Developing an Eating Disorder 363

Chapter Summary 364

Study Questions 366

References 367

11 NUTRITION, EXERCISE, AND SPORTS 369

11.1

Benefits of Fitness 370

11.2 Characteristics of a Good Fitness

Program 371

Mode 371

Duration 371

Frequency 371

Intensity 371

Progression 373

Consistency 373

Variety 373

Achievement and Maintenance of Fitness 373

11.3 Energy Sources for Muscle Use 375

ATP: Immediately Usable Energy 375

Phosphocreatine: Initial Resupply of Muscle ATP 375

Take Action: How Physically Fit Are You? 376

Carbohydrate: Major Fuel for Short-Term, High Intensity, and Medium-Term Exercise 379

Fat: Main Fuel for Prolonged, Low Intensity Exercise 382

Protein: A Minor Fuel Source during Exercise 383

Fuel Use and VO2max 384

11.4 The Body’s Response to Physical Activity 385

Specialized Functions of Skeletal Muscle

Fiber Types 385

Adaptation of Muscles and Body Physiology to Exercise 385

11.5 Power Food: Dietary Advice for Athletes 386

Energy Needs 386

Carbohydrate Needs 387

Fat Needs 390

Protein Needs 390

Take Action: Meeting the Protein Needs of an Athlete: A Case Study 391

Vitamin and Mineral Needs 392

11.6 Fluid Needs for Active Individuals 393

Fluid Intake and Replacement Strategies 395

Water Intoxication 395

Sports Drinks 396

11.7 Food and Fluid Intake before, during, and after Exercise 396

Pre-exercise Meal 396

Fueling during Exercise 397

Recovery Meals 398

Global Perspective: Gene Doping and the Wide World of Sports 399

11.8 Ergogenic Aids to Enhance Athletic Performance 399

Chapter Summary 402

Study Questions 404

References 405

Part 4 Vitamins and Minerals 407

12 THE FAT-SOLUBLE VITAMINS 407

12.1 Vitamins: Essential Dietary Components 408

Absorption of Vitamins 408

Malabsorption of Vitamins 408

©Jules Frazier/Getty Images RF

Transport of Vitamins 409

Storage of Vitamins in the Body 409

Vitamin Toxicity 410

12.2 Vitamin A 410

Vitamin A in Foods 411

Vitamin A Needs 412

Absorption, Transport, Storage, and Excretion of Vitamin A 413

Functions of Vitamin A (Retinoids) 414

Carotenoid Functions 415

Vitamin A Deficiency Diseases 416

Vitamin A Toxicity 417

Global Perspective: Vitamin A Deficiency 419

12.3 Vitamin D 420

Vitamin D2 in Foods 420

Vitamin D3 Formation in the Skin 420

Vitamin D Needs 421

Absorption, Transport, Storage, and Excretion of Vitamin D 421

Functions of Vitamin D 423

Vitamin D Deficiency Diseases 424

Vitamin D Toxicity 425

12.4 Vitamin E 426

Vitamin E in Foods 426

Vitamin E Needs 426

Absorption, Transport, Storage, and Excretion of Vitamin E 427

Functions of Vitamin E 427

Vitamin E Deficiency 428

Vitamin E Toxicity 429

12.5 Vitamin K 429

Vitamin K Sources 429

Vitamin K Needs 430

Absorption, Transport, Storage, and Excretion of Vitamin K 430

Functions of Vitamin K 430

Vitamin K Deficiency 431

Vitamin K Toxicity 431

Take Action: Does Your Fat-Soluble Vitamin Intake Add Up? 432

12.6 Dietary Supplements: Healthful or Harmful? 434

Take Action: A Closer Look at Supplements 436

Chapter Summary 437

Study Questions 439

References 440

13 THE WATER-SOLUBLE VITAMINS 443

13.1 Water-Soluble Vitamin Overview 444

Coenzymes: A Common Role of B-Vitamins 445

Enrichment and Fortification of Grains 446

13.2 Thiamin 447

Thiamin in Foods 448

Thiamin Needs and Upper Level 448

Absorption, Transport, Storage, and Excretion of Thiamin 449

Functions of Thiamin 449

Thiamin Deficiency 450

13.3

Riboflavin 451

Riboflavin in Foods 451

Riboflavin Needs and Upper Level 451

Absorption, Transport, Storage, and Excretion of Riboflavin 452

Functions of Riboflavin 452

Riboflavin Deficiency 453

13.4 Niacin 453

Niacin in Foods 454

Niacin Needs and Upper Level 455

Absorption, Transport, Storage, and Excretion of Niacin 455

Functions of Niacin 455

Niacin Deficiency 456

Pharmacological Use of Niacin 457

13.5

Pantothenic Acid 458

Pantothenic Acid in Foods 458

Pantothenic Acid Needs and Upper Level 458

Absorption, Transport, Storage, and Excretion of Pantothenic Acid 458

Functions of Pantothenic Acid 459

Pantothenic Acid Deficiency 459

13.6 Biotin 460

Sources of Biotin: Food and Microbial Synthesis 460

Biotin Needs and Upper Level 460

Absorption, Transport, Storage, and Excretion of Biotin 461

Functions of Biotin 461

Biotin Deficiency 461

13.7

Vitamin B-6 462

Vitamin B-6 in Foods 462

Vitamin B-6 Needs and Upper Level 462

Absorption, Transport, Storage, and Excretion of Vitamin B-6 463

Functions of Vitamin B-6 463

Vitamin B-6 Deficiency 464

Pharmacological Use of Vitamin B-6 464

13.8 Folate 465

Folate in Foods 465

Dietary Folate Equivalents 466

Folate Needs 466

Upper Level for Folate 466

Absorption, Transport, Storage, and Excretion of Folate 466

Culinary Perspective: Beans, Lentils, and Dried Peas 467

Functions of Folate 467

Clinical Perspective: Folate and the Cancer Drug Methotrexate 468

Folate Deficiency 468

Clinical Perspective: Neural Tube

13.9

Defects 470

Vitamin B-12 471

Vitamin B-12 in Foods 471

Vitamin B-12 Needs and Upper Level 472

Absorption, Transport, Storage, and Excretion of Vitamin B-12 472

Functions of Vitamin B-12 473

Vitamin B-12 Deficiency 473

13.10 Choline 475

Choline in Foods 475

Choline Needs and Upper Level 475

Absorption, Transport, Storage, and Excretion of Choline 476

Functions of Choline 476

Choline Deficiency 477

Take Action: B-Vitamin Supplements 477

13.11

Vitamin C 478

Vitamin C in Foods 478

Vitamin C Needs 478

Upper Level for Vitamin C 479

Absorption, Transport, Storage, and Excretion of Vitamin C 479

Functions of Vitamin C 479

Vitamin C Deficiency 481

Vitamin C Intake above the RDA 483

Take Action: Spotting Fraudulent Claims for Vitamins and Vitamin-like

Substances 484

Chapter Summary 485

Study Questions 487

References 488

14 WATER AND MAJOR MINERALS 491

14.1 Water 492

Water in the Body: Intracellular and Extracellular Fluids 492

Functions of Water 495

Water in Beverages and Foods 496

Water Needs 498

Regulation of Water Balance 499

Global Perspective: Water for Everyone 503

14.2 Overview of Minerals 504

Food Sources of Minerals 504

Absorption and Bioavailability of Minerals 505

Transport and Storage of Minerals 506

Excretion of Minerals 506

Functions of Minerals 506

Mineral Deficiencies 507

Mineral Toxicity 507

14.3

Sodium (Na) 507

Sodium in Foods 507

Culinary Perspective: Sea and Specialty Salts 508

Sodium Needs 509

Absorption, Transport, Storage, and Excretion of Sodium 510

Functions of Sodium 510

Sodium Deficiency 510

Excess Sodium Intake and Upper Level 511

14.4

Potassium (K) 512

Potassium in Foods 512

Potassium Needs 513

Absorption, Transport, Storage, and Excretion of Potassium 513

Functions of Potassium 513

Potassium Deficiency 513

Excess Potassium and Upper Level 514

14.5

Chloride (Cl) 514

Chloride in Foods 514

Chloride Needs 515

Absorption, Transport, Storage, and Excretion of Chloride 515

Functions of Chloride 515

Chloride Deficiency 515

Upper Level for Chloride 515

Clinical Perspective: Hypertension and Nutrition 516

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14.6 Calcium (Ca) 519

Calcium in Foods 520

Calcium Needs 521

Calcium Supplements 522

Calcium Absorption, Transport, Storage, Regulation, and Excretion 522

Functions of Calcium 524

Take Action: Estimate Your Calcium Intake 527

Clinical Perspective: Osteoporosis 528

Take Action: Bone Health 531

Potential Health Benefits of Calcium 531

Upper Level for Calcium 531

14.7 Phosphorus (P) 532

Phosphorus in Foods 532

Phosphorus Needs 532

Absorption, Transport, Storage, and Excretion of Phosphorus 532

Functions of Phosphorus 533

Phosphorus Deficiency 533

Toxicity and Upper Level for Phosphorus 533

14.8 Magnesium (Mg) 533

Magnesium in Foods 533

Magnesium Needs 534

Absorption, Transport, Storage, and Excretion of Magnesium 534

Functions of Magnesium 535

Magnesium Deficiency

Upper Level for Magnesium

14.9 Sulfur (S) 536

Chapter Summary 538

Study Questions 540

References 542

15 TRACE MINERALS

545

15.1 Iron (Fe) 546

Zinc Deficiency 555

Zinc Toxicity 555

Take Action: Iron and Zinc Intake in a Sample

15.3

Vegan Diet 556

Copper (Cu) 556

Copper in Foods 556

Dietary Needs for Copper 556

Absorption, Transport, Storage, and Excretion of Copper 557

Functions of Copper 557

Copper Deficiency 558

Copper Toxicity 558

15.4

Manganese (Mn) 558

Manganese in Foods 558

Dietary Needs for Manganese 559

Absorption, Transport, Storage, and Excretion of Manganese 559

Functions of Manganese 559

Manganese Deficiency and Toxicity 559

15.5

Iodine (I) 560

Iodine in Foods 560

Dietary Needs for Iodine 561

Absorption, Transport, Storage, and Excretion of Iodine 561

Functions of Iodine 561

Iodine Deficiency Disorders (IDD) 561

Iron in Foods 546

Iron Needs 546

Absorption, Transport, Storage, and Excretion of Iron 547

Functions of Iron 549

Iron Deficiency 551

Iron Overload and Toxicity 552

15.2 Zinc (Zn) 553

Zinc in Foods 553

Dietary Needs for Zinc 554

Absorption, Transport, Storage, and Excretion of Zinc 554

Functions of Zinc 555

15.8

Iodine Toxicity 562

Selenium (Se) 564

Selenium in Foods 564

Dietary Needs for Selenium 565

Absorption, Transport, Storage, and Excretion of Selenium 565

Functions of Selenium 565

Selenium Deficiency 566

Selenium Toxicity 566

Chromium (Cr) 567

Chromium in Foods 567

Dietary Needs for Chromium 567

Absorption, Transport, Storage, and Excretion of Chromium 567

Functions of Chromium 567

Chromium Deficiency and Toxicity 567

Fluoride (F) 568

Fluoride in Foods 568

Dietary Needs for Fluoride 568

Absorption, Transport, Storage, and Excretion of Fluoride 568

Functions of Fluoride 568

Fluoride Deficiency and Toxicity 569

Take Action: Is Your Local Water Supply Fluoridated? 571

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15.9 Molybdenum (Mo) and Ultratrace

Minerals 571

Global Perspective: The e-Library of Evidence for Nutrition Actions 572

Clinical Perspective: Nutrients, Diet, and Cancer 573

Chapter Summary 576

Study Questions 578

References 579

Part 5 Nutrition Applications in the Life Cycle 581

16 NUTRITIONAL ASPECTS OF PREGNANCY AND BREASTFEEDING 581

16.1 Pregnancy 582

Prenatal Developmental Stages: Conception, Zygotic, Embryonic, and Fetal 583

Nourishing the Zygote, Embryo, and Fetus 587

16.2 Nutrient Needs of Pregnant Women 588

Energy Needs 589

Nutrients Needed for Building New Cells 589

Nutrients Needed for Bone and Tooth Development 591

Expert Perspective from the Field: Grains and Folic Acid Fortification 592

Pregnant Women Do Not Have an Instinctive Drive to Consume More Nutrients 592

16.3 Diet and Exercise Plan for Pregnancy 593

Prenatal Vitamin and Mineral Supplements 595

Physical Activity during Pregnancy 595

Global Perspective: Pregnancy and Malnutrition 596

16.4 Maternal Weight and Pregnancy

Outcome 597

Maternal Prepregnancy

Weight 597

Maternal Weight Gain 597

Pattern of Maternal Weight Gain 599

16.5 Nutrition-Related Factors Affecting Pregnancy Outcome 599

Young Maternal Age 599

Maternal Eating Patterns 600

Maternal Health 600

Maternal Sociocultural Factors 602

Maternal Food Supply 602

Maternal Lifestyle 603

Take Action: Healthy Diets for Pregnant Women 605

Clinical Perspective: Nutrition-Related Physiological Changes of Concern during Pregnancy 606

16.6 Lactation 608

Milk Production 608

16.7 Nutrient Needs of Breastfeeding Women 610

Maternal Nutritional Status 610

Food Choices during Lactation 611

16.8 Factors Affecting

Lactation 612

Maternal Weight 612

Maternal Age 612

Maternal Eating Patterns 612

Maternal and Infant Health 612

Sociocultural Factors 613

Maternal Food Supply 614

Maternal Lifestyle Choices 614

Take Action: Investigating Breastfeeding 615

Chapter Summary 616

Study Questions 618

References 619

17 NUTRITION DURING THE GROWING YEARS 621

17.1 Growing Up 622

Height and Weight 622

Body Composition 623

Body Organs and Systems 623

17.2 Physical Growth 624

Tracking Growth 624

Using Growth Chart Information 626

17.3 Nutrient Needs 627

Global Perspective: Autism 628

Energy 628

Protein 628

Fat 629

Carbohydrate 629

Water 629

Vitamins and Minerals 630

17.4 Feeding Babies: Human Milk and Formula 632

Nutritional Qualities of Human Milk 632

Nutritional Qualities of Infant Formula 633

Comparing Human Milk and Infant Formula 634

Feeding Technique 635

Preparing Bottles 636

17.5 Feeding Babies: Adding Solid Foods 638

Deciding When to Introduce Solid Foods 638

Rate for Introducing Solid Foods 640

Sequence for Introducing Solid Foods 640

Weaning from the Breast or Bottle 642

Learning to Self-feed 642

Clinical Perspective: Potential Nutrition-Related Problems of Infancy 643

17.6 Children as Eaters 644

Appetites 645

When, What, and How Much to Serve 646

Food Preferences 647

Mealtime Challenges 648

Take Action: Getting Young Bill to Eat 649

Clinical Perspective: Potential Nutrition-Related Problems of Childhood 650

17.7 Teenage Eating Patterns 652

Factors Affecting Teens’ Food Choices 652

Helping Teens Eat More Nutritious Foods 653

Take Action: Evaluating a Teen Lunch 654

Clinical Perspective: Potential Nutrition-Related Problems of Adolescence 655

Chapter Summary 656

Study Questions 658

References 659

18 NUTRITION DURING THE ADULT YEARS 661

18.1 Physical and Physiological Changes during Adulthood 662

Usual and Successful Aging 664

Factors Affecting the Rate of Aging 664

Take Action: Stop the Clock! Are You Aging Healthfully? 666

18.2

Nutrient Needs during Adulthood 667

Defining Nutrient Needs 668

18.3 Factors Influencing Food Intake and Nutrient Needs 672

Physical and Physiological Factors 672

Psychosocial Factors 680

Economic Factors 681

18.4

Nutrition Assistance Programs 682

18.5 Nutrition-Related Health Issues of the Adult Years 683

Alcohol Use 684

Slowed Restoration of Homeostasis 684

Alzheimer Disease 684

Arthritis 685

Take Action: Helping Older Adults Eat Better 686

Clinical Perspective: Complementary and Alternative Health Approaches 687

Chapter Summary 691

Study Questions 693

References 694

Appendices

A Human Physiology: A Tool for Understanding Nutrition A-1

B Chemistry: A Tool for Understanding Nutrition A-25

C Detailed Depictions of Glycolysis, Citric Acid Cycle, Electron Transport Chain, Classes of Eicosanoids, and Homocysteine Metabolism A-48

D Dietary Advice for Canadians A-54

E The Food Lists for Diabetes: A Helpful Menu Planning Tool A-66

F Fatty Acids, Including Omega-3 Fatty Acids, in Foods A-80

G Metropolitan Life Insurance Company Height-Weight Table and Determination of Frame Size A-82

H English-Metric Conversions and Nutrition Calculations A-85

I Caffeine Content of Beverages, Foods, and Over-the-Counter Drugs A-90

J Dietary Reference Intakes (DRI) A-92

K CDC Growth Charts A-104

L Sources of Nutrition Information A-113

M Dietary Intake and Energy Expenditure Assessment A-116

N Food Composition Table A-125 Glossary Terms G-1 Index I-1

A nutritious, delicious, and varied diet is key to good health and longevity. To learn more, carefully study this text and visit nutrition.gov.

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1 The Science of Nutrition

Learning Objectives

After studying this chapter, you will be able to

1. Define the terms nutrition, carbohydrates, proteins, lipids (fats and oils), vitamins, minerals, water, and calories

2. Use the physiological fuel values of energy-yielding nutrients to determine the total energy content (calories) in a food or diet.

3. Describe the major characteristics of the North American diet and the food behaviors that often need improvement.

4. Describe the factors that affect our food choices.

5. Discuss the components and limitations of nutritional assessment.

6. List the attributes of lifestyles that are consistent with Healthy People 2020 goals and those that contribute to the leading causes of death in North America.

7. Describe the role of genetics in the development of nutrition-related diseases.

8. Explain how the scientific method is used in developing hypotheses and theories in the field of nutrition.

9. Identify reliable sources of nutrition information.

Chapter Outline

1.1 Nutrition Overview

Expert Perspective from the Field: Functional Foods

1.2 Energy Sources and Uses

1.3 The North American Diet

Global Perspective: The Price of Food

1.4 Nutritional Health Status

Clinical Perspective: Genetics and Nutrition

1.5 Using Scientific Research to Determine Nutrient Needs

1.6 Evaluating Nutrition Claims and Products

IN OUR LIFETIMES, WE WILL eat about 60 tons of food served at 70,000 meals and countless snacks. Research over the last 50 years has shown that the foods we eat have a profound impact on our health and longevity.

A healthy diet—especially one rich in fruits and vegetables—coupled with frequent exercise can prevent and treat many age-related diseases. 1 In contrast, eating a poor diet and getting too little exercise are risk factors for many common lifethreatening, chronic diseases, such as cardiovascular (heart) disease, diabetes, and certain forms of cancer. 2,3 Another diet-related problem, drinking too much alcohol, can impair nutritional status and is associated with liver disease, some forms of cancer, accidents, and suicides. As you can see in Figure 1-1, diet plays a role in the development of most of the leading causes of death in the U.S. The combination of poor diet and too little physical activity contributes to well over half of these deaths. 3,4

We live longer than our ancestors did, so preventing age-related diseases is more important now than ever before. Today, many people want to know more about how nutritious dietary choices can bring the goal of a long, healthy life within reach.5 They may wonder what the best dietary choices are, how nutrients contribute to health, or if multivitamin and mineral supplements are needed. How can people know if they are eating too much saturated fat, trans fat, or cholesterol? Why are carbohydrates important? Is it possible to get too much protein?

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