byDr.Jen
Peptidesfor motherhood
byDr.Jen
DR. JEN PFLEGHAAR
Integrative Medicine Physician
Hello! A little about me!
Dr. Jen Pfleghaar is a double board certified physician in Integrative Medicine and Emergency Medicine. She attended medical school at Lake Erie College of Osteopathic Medicine. She then went on to residency at St Vincent’s Mercy Medical Center for Emergency Medicine and spent one year flying with Life Flight as a flight physician. Dr. Jen now works at local emergency rooms in the community and her office in Perrysburg, OH practicing Integrative Medicine and Medical Aesthetics She is a graduate from The University of Arizona: Andrew Weil Center for Integrative Medicine's fellowship program Dr Jen loves speaking and lectures to physicians at conferences including the AOA (American Osteopathic Association). She hosts the podcast The Integrative Health Podcast with Dr. Jen. Her own health history of Hashimoto’s (which is now in remission) sparked her interest in Integrative Medicine She is very passionate about helping patients with chronic disease and teaching them now to let the body heal itself She is a published author of the book- Eat Sleep Move Breathe: A Beginner's Guide to a Healthy Lifestyle. She is a board member for IDA- Invisible Disabilities Association Her hobbies include spending time with her husband and four children, being in nature, weightlifting, wake surfing on the Maumee river and reading the Bible.
”We
are often so stressed and anxious that it affects not only our personal health but our family. Working on our personal health will have a ripple effect to everyone around us!”
Dr. Jen
ARE YOU A BUSY MOTHER?
Biohacking as a mother! Here we go!
I think the hardest part about being a mother is comparing yourself to all the “other” mothers out there AND also comparing yourself to some biohacker on Instagram that has never had children First of all comparison is the thief of joy! Don’t do it! Live your own amazing life and know that your introduction can not be compared to someone’s else finale
This verse helps me a lot “Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your request to God ” Philippians 4:6 NIV We are often so stressed and anxious that it affects not only our personal health but our family. Working on our personal health will have a ripple effect to everyone around us!
Now what to do? First (always) work on your gut health. Figure out if you have problems there first that might be making your feel tired, mess with your hormones or be causing you discomfort You can find more information about how to heal your gut at my website. www.healthybydrjen.com
After you have your gut health improved also make sure you are setting your sites on optimal sleep and movement. These are also nonnegotiables for being optimal and biohacking as a mother.
Great, now that we have all of that figured out we can move onto the peptides that can help support you as you age and support your optimal self!
PEPTIDES 101
What are peptides?
Peptides are a specific type of bioregulator, characterized by being composed of short chains of amino acids linked together by peptide bonds. While peptides are a subset of bioregulators, they are distinct in that they are typically smaller in size compared to proteins and have specific functions in cell signaling, neurotransmission, hormone regulation, and other physiological processes.
What are some peptides in our body?
Insulin: Produced by the pancreas, insulin regulates blood sugar levels by promoting the uptake of glucose into cells for energy or storage.
Oxytocin: Often referred to as the "love hormone," oxytocin plays a role in social bonding, childbirth, and lactation. It is released during childbirth and breastfeeding and promotes uterine contractions and milk ejection.
Growth hormone (GH): Stimulates growth, cell reproduction, and regeneration in humans and animals. It plays a key role in childhood growth, muscle mass maintenance, and metabolism regulation.
BEFORE YOU START
Optimize the pillars of health!
Peptides do work better when you optimize your health through nutrition, movement, breath work and sleep!
In my experience, peptides will give you more bang for your buck if health is optimized. However, sometimes you will need certain peptides to move the needle so you can optimize the rest of your health.
Need help on the four pillars of health? I got you! If it feels tough to tackle all of these at once- just do one things at a time. Take 4 weeks to really focus on each pillar and set goals for yourself.
Remember, working o nutrition, breathwork, movement and sleep will help your overall health! You got this, it’s all about mindset!
NUTRITION
Protein, Veggies and healthy fats!
Avoid High fructose corn syrup, inflammatory oils (canola, soy, sunflower), food dyes. pesticides (EWG lists dirty dozen, clean fifteen)
Eat grass fed meat, wild salmon, colorful fruits and vegetables
Balance your blood sugar
SLEEP
Sleep is restorative!
Environment
Room- keep dark, comfortable temperature, use bed for sleeping and sex only
Loud noises or traffic- try a sleep machine
Weighted Blankets: Deep Touch Pressure (DTP)
DTP helps the brain to release serotonin, melatonin and dopamine.
Blue light blocking glasses- blue light suppresses melatonin
Limit EMFs: Electromagnetic fields: wifi, cellphones, electric blankets, electric clocks, power lines, ect.
Supplements
Melatonin
L-theanine
Magnesium
Tart Cherry Juice
Chamomile Tea
MOVEMENT
Walking and weights!
Walk daily (best after meals, grounding also great) Great way to also set your circadian rhythm
Lift weights 3-4 times a week
Stretch daily
BREATHWORK
Prayer, breathwork
Apps on the phone: Calm, Youversion
Gratitude journal
“A Joyful heart is good medicine.” Proverbs 17:22
4-7-8 Breath work
What is it?
5-amino-1MQ is a compact molecule that impedes the function of nicotinamide Nmethyltransferase (NNMT), an enzyme crucial in metabolism and energy regulation, particularly within fat tissue. Through NNMT inhibition, 5-amino-1MQ stimulates the elevation of nicotinamide adenine dinucleotide (NAD+), a vital cofactor essential for cellular metabolism.
5-AMINO 1 MQ
This leads to an enhanced metabolic rate and the activation of a gene recognized as sirtuin-1 (SIRT1), commonly dubbed the "longevity gene " SIRT1 plays a role in diminishing the likelihood of numerous conditions, including diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer
Nicotinamide N-methyltransferase (NNMT) is an enzyme pivotal in cellular metabolism and energy control. Elevated NNMT levels disrupt proper metabolism, correlating with conditions like type-2 diabetes and obesity, as they hinder fat burning and promote fat accumulation
5-amino 1 MQ cames a a pill. It’s used 1 - 3 times a day. Oral dosing 50 - 100 mg daily Can use with NAD+
ref: PMC5826726
Please consult with your personal doctor before taking any new medications or supplements
Dhh-b (dihydrohonokiol-B bioactive honokiol extracted from magnolia bark) 1-2 capsules during the day (similar anxiolytic effect of to Benzos) Used for anxiety. Also appears to have neuroprotectice activity. Studies on neuroprotective effects
What is it? Research
“DHH-B is a potent anxiolytic-like agent and that GABA(A) receptorgated Cl(-)-channel complex is involved in the anxiolytic-like efficacy of DHH-B.
PMID: 11370711 DOI: 10 1211/0022357011775848
DHH-B
D I H Y D R O H O
N O K I O L - B
B I O A C T I V E
H O N O K I O L
E X T R A C T E D
F R O M
M A G N O L I A
B A R K
This data indicates that DHH-B demonstrates neuroprotective effects against Abeta by stimulating GABA(C) receptors.
PMID: 15899548
Dosing: 10 mg one to two times daily
Pain modulation:
Some studies have explored the use of KPV-containing peptides for their analgesic (pain-relieving) properties. These peptides may interact with pain receptors or signaling pathways in the body to alleviate pain
KPV
THE KPV PEPTIDE IS A SHORT PEPTIDE SEQUENCE COMPOSED OF THREE AMINO ACIDS: LYSINE (K), PROLINE (P), AND VALINE (V).
Wound healing
Peptides containing the KPV sequence have also been investigated for their role in promoting wound healing and tissue repair. These peptides may stimulate cellular processes involved in tissue regeneration and remodeling
Inflammation modulation
Certain peptides, including those containing the KPV sequence, have been studied for their antiinflammatory effects. These peptides may help regulate the body's immune response and reduce inflammation in various conditions
How do you use it?
KPV comes in sprays, cream and pills
Work with your doctor to deterine what would be best for your condition.
Benefits:
Anti-inflammatory Effects: BPC-157 has demonstrated antiinflammatory properties, which may contribute to its ability to reduce pain and inflammation associated with injury or conditions such as arthritis.
BPC 157
BODY PROTECTION COMPOUND-157, IS A SYNTHETIC PEPTIDE CONSISTING OF 15 AMINO ACIDS
Sccelerated Healing: BPC-157 has been shown in animal studies to promote the healing of various tissues, including muscle, tendon, ligament, and bone. It may stimulate the formation of new blood vessels (angiogenesis) and enhance the regeneration of damaged tissues.
Gastrointestinal Health: Research suggests that BPC-157 may have protective effects on the gastrointestinal tract, promoting the healing of ulcers and other digestive disorders
Joint Health: BPC-157 has shown promise in protecting and repairing cartilage and other joint tissues, making it potentially beneficial for conditions like osteoarthritis and sports-related injuries.
How does it work?
GHRH peptides work by binding to specific receptors on the surface of somatotropic cells in the pituitary gland, triggering a cascade of signaling events that ultimately result in the release of growth hormone into the bloodstream.
Stimulation of Growth
Growth hormone plays a crucial role in promoting growth and development during childhood and adolescence GHRH peptides may be used therapeutically to stimulate growth in children with growth hormone deficiency or other growth disorders Growth hormone is known to have anabolic effects on skeletal muscle, promoting muscle growth, repair, and recovery GHRH peptides may be used by athletes and bodybuilders to enhance muscle growth and improve athletic performance.
GHR PEPTIDES
GROWTH HORMONERELEASING HORMONE (GHRH) PEPTIDES ARE A CLASS OF COMPOUNDS THAT STIMULATE THE RELEASE OF GROWTH HORMONE (GH) FROM THE PITUITARY GLAND IN THE BRAIN.
Regulation of Metabolism
Growth hormone influences metabolism by promoting the breakdown of fats (lipolysis) and stimulating the production of insulinlike growth factor 1 (IGF-1), which mediates many of the metabolic effects of growth hormone. GHRH peptides may be used to enhance metabolism and promote fat loss in certain individuals.
Other things
Anti-aging Effects: Growth hormone has been implicated in the aging process, and declining levels of growth hormone are associated with age-related changes in body composition, metabolism, and physical function. Some individuals use GHRH peptides as part of antiaging or rejuvenation therapies to restore youthful levels of growth hormone and mitigate age-related decline
Cognitive Function: There is evidence to suggest that growth hormone may play a role in cognitive function and brain health GHRH peptides have been studied for their potential cognitive-enhancing effects and may be of interest in the field of cognitive aging and neurodegenerative diseases.
Benefits:
Stimulating Collagen Production:
GHK-Cu is believed to promote the synthesis of collagen, a protein essential for maintaining the structure and elasticity of the skin. Increased collagen production can lead to smoother, firmer skin and a reduction in the appearance of wrinkles and fine lines.
GHK-CU
Enhancing Wound Healing: GHK-Cu has been shown to accelerate wound healing by promoting the migration of skin cells, reducing inflammation, and stimulating the production of growth factors involved in tissue repair.
Antioxidant Activity: GHK-Cu exhibits antioxidant properties, which help protect skin cells from oxidative stress caused by free radicals. This antioxidant activity may contribute to its anti-aging effects and ability to improve skin texture and tone.
Hair Growth Stimulation: Some research suggests that GHK-Cu may promote hair growth by stimulating the proliferation of hair follicle cells and prolonging the anagen (growth) phase of the hair growth cycle
Improves glucose uptake, improved insulin secretion, reduces stress and anxiety, increases with exercises, regulates appetite, increases with mindfulness and human connection.
OXYTOCIN
Produced primarily in the hypothalamus region of the brain and released by the pituitary gland, oxytocin plays a crucial role in various physiological and psychological processes
A nasal spray is the most common way to take it with doses ranging from 10 - 100 units. Work with your doctor for dosing!
Some people pair it with PT-141 for arousal amd intimacy indications. There have been studies on oxytocins role in autism.
How it works:
Insulin secretion: GLP-1 stimulates the release of insulin from pancreatic beta cells in response to elevated blood glucose levels. This helps to lower blood sugar levels after meals, preventing hyperglycemia.
GLP-1
G L U C A G O N -
L I K E P E P T I D E - 1
( G L P - 1 ) I S A
H O R M O N E
P R O D U C E D I N
T H E
I N T E S T I N E S ,
S P E C I F I C A L L Y
I N T H E
I N T E S T I N A L L -
C E L L S , I N
R E S P O N S E T O
F O O D I N T A K E .
Glucagon inhibition: GLP-1 suppresses the secretion of glucagon from pancreatic alpha cells Glucagon normally raises blood sugar levels by promoting the breakdown of glycogen in the liver, so inhibiting its release helps to prevent excessive glucose production.
Slowing gastric emptying: GLP-1 slows down the rate at which food moves through the stomach and into the intestines This helps to regulate the absorption of nutrients and glucose from the digestive system, contributing to better blood sugar control.
Satiety: GLP-1 also acts on the brain to promote feelings of fullness and satiety, which can help to reduce food intake and contribute to weight management.
Benefits
May have synergistic effects on improving glucose metabolism and insulin secretion. By targeting multiple pathways involved in blood sugar regulation, GLP-1/GIP peptides may offer potential therapeutic benefits for conditions such as type 2 diabetes mellitus and obesity.
GLP-1/GIP
G L P - 1 / G I P
P E P T I D E R E F E R S
T O A
C O M B I N A T I O N
O F T W O
P E P T I D E S :
G L U C A G O N - L I K E
P E P T I D E - 1 ( G L P -
1 ) A N D G A S T R I C
I N H I B I T O R Y
P O L Y P E P T I D E
( G I P .
GLP-1
GLP-1 is a hormone produced by the intestines in response to food intake It plays a crucial role in regulating blood sugar levels by stimulating insulin secretion from pancreatic beta cells, inhibiting glucagon secretion (which helps lower blood sugar), slowing gastric emptying, and promoting satiety
GIP
GIP, also known as glucosedependent insulinotropic peptide, is another hormone produced by the intestines in response to nutrient ingestion. Its primary role is to stimulate insulin release from pancreatic beta cells in response to elevated blood glucose levels.
Examples
Zepbound Monjaro
Should work with a doctor to prescribe and get you ready to be on these peptides!
IMPORTANT
Contradictions:
Those with a personal or family history of medullary thyroid carcinoma. Patients with a history of MEN 2 (multiple endocrine neoplasia syndrome type. (In rats, tirzepatide caused thyroid C-cell tumors but it isn’t yet known if the drug poses any risk for the increase of C-cell tumors in humans.)
Relative:
History pf pancreatitis, gastroparesis
Some side effects: Pancreatitis, gastroparesis, suicidal ideations, GERD, return of weight,
Side Effects
Difficulty in breathing or swallowing. fast heartbeat. gaseous stomach pain. heartburn. recurrent fever. skin itching, rash, or redness. stomach fullness. swelling of the face, throat, or tongue.
STUDIES
The SURMOUNT-4 Randomized Clinical Trial
https://jamanetwork.com/journals/jama/fullarticle/2 812936
Interventions
Participants (n = 783) enrolled in an open-label lead-in period received once-weekly subcutaneous maximum tolerated dose (10 or 15 mg) of tirzepatide for 36 weeks. At week 36, a total of 670 participants were randomized (1:1) to continue receiving tirzepatide (n = 335) or switch to placebo (n = 335) for 52 weeks.
Limitations
This study has limitations. First, the design of this study did not allow dose adjustments after randomization and did not evaluate the effects of intensive behavioral therapy on the maintenance of body weight reduction. Second, those who tolerated initial treatment with 10mg or 15-mg tirzepatide may represent a subgroup of the general population.
Conclusions
After achieving clinically meaningful weight reduction during a 36-week tirzepatide lead-in treatment period, adults with obesity or overweight who continued treatment with maximum tolerated dose tirzepatide for an additional 52 weeks demonstrated superior weight maintenance and continued weight reduction compared to those who switched to placebo.
STUDIES
The STEP 4 Randomized Clinical Trial
https://jamanetwork.com/journals/jama/fullarticle/2812936
Interventions A total of 902 participants received once-weekly subcutaneous semaglutide during run-in. After 20 weeks (16 weeks of dose escalation; 4 weeks of maintenance dose), 803 participants (89.0%) who reached the 2.4-mg/wk semaglutide maintenance dose were randomized (2:1) to 48 weeks of continued subcutaneous semaglutide (n = 535) or switched to placebo (n = 268), plus lifestyle intervention in both groups.
Limitations
This study has several limitations. First, there was inflexibility in the run-in period, which limited assessment to only participants tolerating the strict dose titration schedule, unlike how the medication might be used in clinical practice, with some patients not tolerating the medication after it is prescribed. The run-in period, as well as the trial setting, likely resulted in a study population who was both more tolerant of semaglutide and more adherent to medication use than would be the case in a typical setting. Because of this, the average effect size in clinical use is likely to be less than was seen in this trial. Second, there was no assessment of adherence to lifestyle interventions. Third, while the withdrawal design is a strength, it can also result in selection bias and favorable carryover effects to the randomized period, potentially resulting in overestimation of weight loss with continued semaglutide compared with what would be expected in a typical individual. To lessen any potential effect of the long half-life of semaglutide on adverse event reporting, adverse events were counted only during the randomized period if onset was after randomization.
Conclusions
Among adults with overweight or obesity who completed a 20week run-in period with subcutaneous semaglutide, 2.4 mg once weekly, maintaining treatment with semaglutide compared with switching to placebo resulted in continued weight loss over the following 48 weeks.
STUDIES
Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension
https://pubmed.ncbi.nlm.nih.gov/35441470/
Conclusions: One year after withdrawal of once-weekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained two-thirds of their prior weight loss, with similar changes in cardiometabolic variables. Findings confirm the chronicity of obesity and suggest ongoing treatment is required to maintain improvements in weight and health.
Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus
https://pubmed.ncbi.nlm.nih.gov/32628589/
Conclusion: Although semaglutide, dapaglifrozin, and canagliflozin have a large weight loss effect, it is important to pay attention to muscle loss because a decrease in FFM was observed.
Clinical effectiveness of semaglutide on weight loss, body composition, and muscle strength in Chinese adults
https://pubmed.ncbi.nlm.nih.gov/37916360/
Objective: The aim of this study was to investigate the clinical effectiveness of semaglutide on weight loss, body composition and muscle strength in the Chinese population with obesity. Patients and methods: Data were retrospectively analyzed for participants prescribed semaglutide in 2021 and 2022 from a Chinese weight management clinic. Changes in weight, body composition, biochemical indicators, calf circumference and handgrip strength were collected. Body fat and skeletal muscle were also measured using the bioelectrical impedance analysis. Paired t-test was used to compare the values after 6 months of treatment with the baseline values.
Results: A total of 53 obese patients received 24 weeks of lifestyle intervention plus semaglutide treatment.
Conclusions: In a real-world setting, semaglutide can reduce the weight and fat of obese patients while effectively maintaining muscle mass and muscle strength.resulted in continued weight loss over the following 48 weeks.
GLP-1/GIP
Work with your doctor!
Fiirst!
Balance hormones
Fix gut health
Liver detox
Lift Weights
Prioritize Protein
One important thing is to find a guide to help you in your health journey! I am here for you! Facebook Group
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