OUR TECHNOLOGY
Astrea Bioseparations Ltd offers SNAP® and Evolve®D columns to support a wide variety of chromatographic processes and biopharmaceutical applications. These columns provide cost-effective, high-performance, easy-to-use, and scalable technology. Our extensive packing service further enhances their suitability for seamless integration into diverse workflows. Designed for both speed and precision, we deliver fast turnaround times, personalized support, and the flexibility to pack nearly every resin, ensuring high-quality results every time.
Successful chromatographic separations in the downstream processing workflow rely on effective column packing. By ensuring uniform flow distribution, minimizing pressure drops, and maintaining consistent packing conditions, biopharmaceutical manufacturers can improve process efficiency and safeguard the integrity of their therapeutic products. As biopharmaceutical demand continues to rise, optimizing column packing processes will remain critical to the success and sustainability of operations in the competitive landscape.
The variability of chromatographic resin properties and the complex interplay of many packing parameters underscore why column packing is as much an art as it is a science. Being able to optimize packing for different resins, flow rates, and purification objectives requires not only technical expertise but also hands-on experience.
By outsourcing column packing to Astrea Bioseparations, biopharmaceutical companies benefit from timely delivery of prequalified, process-ready columns that are accompanied by all necessary documentation to integrate column quickly into downstream processing lines, saving valuable time and resources.
Benefits
• Rapid turnaround times; delivery approximately 21 days
• Reduced process downtime
• Cost effective compared to in-house packing
• Highly reproducible performance
• Column diameters from 10 mm to 600 mm
• Columns packed in ISO 7 cleanrooms
Flexible resin choices
• Packing service available for all Astrea Bioseparations resins
• Supports third-party resin suppliers
• Wide range of packable resin types
• Hardware offers resin recovery options
• Evaluation of used resin available
Global experts & support
• Expert column packing operations based in Europe (Isle of Man) and US (Canton, MA)
• Global team of Field Application Specialists (FAS)
• Documentation for seamless process integration
PRODUCT FORMATS
SNAP® columns: From R&D to clinical production
SNAP® columns are highly configurable, offering the versatility to evaluate an array of process variables and resin types during process development. In their process ready format, they provide a seamless transition from early-stage work to clinical manufacturing.
Our packing service can prepare SNAP® or process-ready SNAP® columns with your choice of resin, saving time and allowing teams to focus on exploring purification strategies before moving into a controlled, regulated
Designed for purpose
SNAP® columns:
• Flexible and scalable
• Available in diameters of 10,15, 25, 35, and 50 mm
• Column tube lengths from 125 mm to 1 M
• Material options available
• Process-ready option: Bioprocess-ready materials with supporting documentation
Packed for you
columns:
Wide range of resin types
Multiple bed heights available
Packed in ISO 7 cleanrooms
Performance Certificate of Conformity supplied
Bioburden statement provided on process-ready SNAP®
Height adjustment options (piston length): Short/Short, Short/Long, Long/Long
O-ring options: Viton, Kalrez (or equivalent)
Bed support materials: Polyethylene, stainless steel
Pressure rating (bar): 13–40 bar; Variable across size range and application
Operating temperature (°C): 4–40 °C
PRODUCT FORMATS
Evolve®D pre-packed columns: Built for commercial bioprocessing
Evolve®D pre-packed columns are purpose-designed, plug-and-play solutions for convenient process chromatography. Built on the proven Evolve® platform, they deliver scalable, reliable performance for bioprocessing and biomanufacturing.
Designed for single production campaigns, Evolve®D columns eliminate the need for cleaning and validation, reducing operational burden and mitigating carryover contamination risk.
Packed in ISO 7 cleanroom environments and supplied
Designed for commercial production
Evolve®D pre-packed columns:
• Plug-and-play format; Designed for single production campaigns
• Available in diameters from 70–600 mm; Bed heights of 5 cm, 10 cm, 15 cm, and 20 cm
• Customer-specified bed heights up to 40 cm on 250–600 mm columns
• Non-metallic flow path compatible with high halide and guanidine HCl solutions
• Manufactured using bioprocess-ready materials
Order information
Evolve®D 70–200 mm
Optimized inlet and outlet sizes to accommodate range of process flow rates and minimize pressure drop
Packed for performance
Evolve®D pre-packed columns:
Compatible with all Astrea Bioseparations and supports third-party resins
Packed bed qualified using HETP, asymmetry, and ΔP techniques
Bioburden study performed with results provided Supplied with RSF and CofA for seamless process integration
Expert packing in Europe and USA; global Field Application Specialist support
Evolve®D 70–200 mm cont.
250–600 mm (standard bed height 5–20 cm)
250–600 mm (longer bed height 20–40 cm)
Commitment to quality
Astrea Bioseparations is honored to support the biopharmaceutical industry with products and services that help bring life-saving and improving medicines to market. Regardless of process scale, we are ready to build Purity by Design into each process to ensure quality and speed to market.
Technical support
Astrea Bioseparations provides expert technical support to help optimize purification strategies. Our chromatography specialists are available to assist with process development, troubleshooting, and scalability considerations.
