Adsorbent selection guide Modality
Binding interaction
Plasmid
MiMode PuraBead® HX2
Glycosylated IgG capture & other mixed-mode interations
MiMode PuraBead® CBX1
Host cell proteins, host cell DNA, aggregates
MiMode PuraBead® HL4
Primary capture, host cell protein removal
Q Edge, SP Edge, DEAE, CM PuraBead®
HIC
Host cell DNA, aggregates
Phenyl, Hexyl, Butyl, Octyl PuraBead®
IEX
pDNA purification using pDNAHERO® technology
HIC
Polishing (separation of supercoiled pDNA)
Hexyl PuraBead®
Isoagglutinin removal
IsoClear® A & B XT
Recombinant albumin capture (high ligand density)
Mimetic Blue® SA HL
Plasma-derived albumin capture (high selectivity)
Mimetic Blue® SA HF
IEX + next-gen IEX
Affinity
Plasmaderived therapeutics
Albumin fusion protein
AlbuPure®
IVIG
Mabsorbent®
AEX
Primary capture blood clotting factors (requires affinity polish)
Q PuraBead®
CEX
C1-esterase inhibitor protein capture
CM PuraBead®
HIC
C1-esterase inhibitor protein polish
Phenyl/Hexyl/Butyl/Octyl PuraBead®
Mixed-mode
Capture & purification of plasma-derived proteins
Affinity
MiMode PuraBead®
Fc region
MiMode PuraBead® HL3
Kappa & Lambda light chains, IgGs & fragments, Fab fragments, F(ab’)2, ScFv, domain antibodies, antibody-drug conjugates, bispecifics
MiMode PuraBead® HX2
Glycoprotein & glycosolated protein removal
MiMode PuraBead® CBX1
Capture & polish using mixed-mode interactions
MiMode PuraBead®
Botulinum toxin purification
BTXPure™
Insulin purification
Insulin
Alkaline phosphotase purification Phosphate-binding protein purification (bind phosphate groups) Serine protease capture
IEX
Primary capture, host cell protein removal
HIC
Host cell DNA, aggregates
Mimetic Blue® AP PE PuraBead® p-Aminobenzamidine DEAE/Q PuraBead® Phenyl/Hexyl/Butyl/Octyl PuraBead®
Endotoxin from E. coli
EtoxiClear®
CEX
AAV capture
SP PuraBead®
Mixed-mode
HCP removal
MiMode PuraBead® HL4
Endotoxin
AAV
DEAE/Q PuraBead® Edge
IVIG
Mixed-mode
Recombinant proteins, enzymes, others
Adsorbent recommendation
Kappa & Lambda light chains, IgGs & fragments, Fab fragments, F(ab’)2, ScFv, domain antibodies, antibody-drug conjugates, bispecifics Mixed-mode
Antibodies
Usage
AEX
Empty/full separation
Q PuraBead®
For more information, please visit our website at www.astreabioseparations.com or contact us at sales@astrea-bio.com AlbuPure® is a registered trademark of Albumedix Ltd. All other trademarks, trade names, trade dress, product names and logos are the property of Astrea UK Services Limited. Copyright © 2026 Astrea Bioseparations Ltd. All rights reserved.