Solution Manual For Fundamentals and Design of Drug Delivery Systems, A Textbook with Lab Activities Edition 1 By Wujie Zhang Chapters 1-16
Answers for selected questions Chapter 1 Q2: 1. Interact with nucleic acids through ionic interactions (forming lipid-nucleic acid complex plus protection); 2. Promote cellular uptake (e.g., cell membrane fusion/destabilization and endocytosis).
Chapter 2 Q2: Because of the acidic or alkaline end groups, they are pH-responsive. For example, at low pH conditions, -COOH groups are protonated (no charge) and are more hydrophobic (less soluble); while at high pH conditions, -COOH groups are deprotonated, becoming -COO- groups, which is more hydrophilic (more soluble).
Chapter 3 Q3: a. For IV injection, Cp0 = Cmax = 7.5 mg/L (y-axis intercept of the Cp vs time curve). b. Vd = dose/ Cp0 = 200 mg / 7.5 mg/L = 26.7 L (remains constant for the same drug) when Cp0 = 10 mg/L dose = Vd × Cp0 = 26.7 L × 10 mg/L = 267 mg Q5: carbonyl group – H-bond; positively-charged N – ionic interactions; methyl groups – VDW. Q6: a. E = F – R + S S = 0 (100 % inhibition) R = 71 mg/min E = Cu × Vu = 1 mg/mL × 1 mL/min = 1 mg/min ClR = E/Cp = 1 mg/min / 0.6 mg/mL = 1.67 mL/min b. F = E + R = 72 mg/min 1