Administration (MDA) to treat Ascaris efficacy and the best chance of curing lumbricoides might hookworm infection. be appropriate, although albendazole as combination of Based on nine studies assessed, this two therapies is preferred. According studies infection to cure. Both albendazole (risk evaluated, albendazole (risk difference difference (RD) = -0.08, P < 0.00001) and (RD) = 0.60, P < 0.00001) is found to be mebendazole (risk difference (RD) = - more effective against hookworm than 0.52, P < 0.00001) do not show efficacy mebendazole. In fact, mebendazole (risk against Trichuris trichiura. However, when difference (RD) = -0.06, P < 0.00001) was both are compared, albendazole is more discovered to be ineffective. Albendazole effective despite the poor overall result. as a monotherapy (risk difference (RD) = According to the forest plot, albendazole as 0.78, P < 0.00001) is shown to be the most a combination of three therapies favored to efficacious compared to the other type of cured and exhibited the best efficacy among administration. Contrary to its effect other types of administration. As a on Ascaris lumbricoides, albendazole as a monotherapy (risk difference (RD) = - combination 0.09, P < 0.00001), albendazole is close to of to species was by far the hardest STH two eight therapies (risk difference (RD) = 0.18, P < 0.00001) has being the poorest outcome against hookworm. On trichiura infection. On the other hand, the a mebendazole as a monotherapy (risk monotherapy (risk difference (RD) = - difference (RD) = -0.78, P < 0.00001) has 0.61, P < 0.00001) showed the worst the poorest efficacy. Nevertheless, efficacy outcome. This finding was a complete of mebendazole as a combination of two opposite of WHO recommendation, which (risk difference (RD) = 0.82, P < 0.00001) was as and three (risk difference (RD) = 0.77, P < monotherapy for MDA. The use of 0.00001) therapies are quite high. As a drug mebendazole as a monotherapy to treat that are being administered for MDA, it is STH should be an important matter to be doubtful reconsidered, of monotherapy or mebendazole monotherapy albendazole is already appropriate. Suppose will have a positive impact on Trichuris that mebendazole is still being used, it trichiura infection. After further analysis, might be wise to administer it as a multiple- the authors found that most of the drugs dose therapy (risk difference (RD) = combination 0.96, P < 0.00001), since it has the best against Trichuris trichiura consist of either other the hand, use mebendazole of whereas as mebendazole the use 151 able to that cure Trichuris either that are albendazole efficacious